Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1664

Generic Name


Brand Name

Tofranil, Tofranil-PM


Antidepressants and TCAs

Proposed Mechanism(s) of Action

Increases serotonin and norepinephrine and blocks serotonin and norepinephrine reuptake



Off-Label Use

Enuresis, anxiety, neuropathic pain, chronic pain, cataplexy, insomnia, reduce GI motility in short gut syndrome

Side Effects

Fatigue, lethargy, sedation, constipation, dry mouth, blurred vision, agitation anxiety, headache, insomnia, nausea, vomiting, sweating


Lowered seizure threshold, seizures, QT prolongation, hepatic failure, extrapyramidal symptoms, mania, activation of suicidal ideation, and hyperthermia


Blurred vision, constipation, fatigue, sedation, headache, diarrhea, heartburn, appetite disturbance, weight gain, anxiety, sexual dysfunction, sweating, and rash

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA