Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1658

Generic Name


Brand Name

Neurontin, Gralise


Anticonvulsants, antineuralgic, GABA analogs

Proposed Mechanism(s) of Action

Binds to voltage-sensitive calcium channels via alpha-2 delta subunit, transported across blood-brain barrier and from the gut to the blood via L transport system.


Partial seizures, postherpetic neuralgia

Off-Label Use

Neuropathic pain, chronic pain, restless legs syndrome, cocaine withdrawal, insomnia, diabetic neuropathy, tremors in multiple sclerosis, hot flashes-cancer related, amyotrophic lateral sclerosis (Orphan), anxiety, and bipolar disorder

Side Effects


Sudden unexplained deaths associated with epilepsy.


Fatigue, nystagmus, tremor, ataxia, dizziness, sedation, blurred vision, vomiting, diarrhea, constipation, and weight gain.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber's guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com
  2. Free Drug Online and PDA Software: www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of Psychology, Nova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA