Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1655

Generic Name


Brand Name



Antidepressants, selective serotonin reuptake inhibitors. Escitalopram is the s-isomer of citalopram.

Proposed Mechanism(s) of Action

Escitalopram blocks the presynaptic serotonin reuptake and desensitizes serotonin receptors (especially 5HT1A).


Major depressive disorder and generalized anxiety disorder.

Off-Label Use

Panic disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, insomnia, vasomotor symptoms associated with menopause, and premenstrual dysphoric disorder.

Side Effects

Headaches, nausea, ejaculation disorder, somnolence, and insomnia.


Seizures, mania, and suicidal ideation (all considered rare).


Sexual dysfunction, gastrointestinal upset, insomnia, sedation, tremor, headache, dizziness, sweating, bruising and very rare bleeding, rare hyponatremia, and a potential for SIADH (syndrome of inappropriate antidiuretic hormone secretion).

References and Reading

  1. Physicians’ Desk Reference (62nd ed.). (2007). Montvale: Thomson PDR.Google Scholar
  2. Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  3. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com.
  2. Free Drug Online and PDA Software: www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA