Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1652

Generic Name


Brand Name

Sinequan and Silenor


Tricyclic antidepressants

Proposed Mechanism(s) of Action

Doxepin is hypothesized to be a potent serotonin and norepinephrine reuptake inhibitor. Histamine 1 blockade.


Depression, anxiety, depression associated with alcohol, depression or anxiety associated with organic disease, psychotic depression with anxiety, manic depression, and insomnia.

Off-Label Use

Itching, lichen simplex chronicus, anxiety, insomnia, neuropathic pain, and treatment-resistant depression.

Side Effects

Dry mouth, constipation, blurred vision, headache, agitation, insomnia, anxiety, nausea, vomiting, sweating, confusion, dizziness, and orthostasis.


Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, mania, potential for activation of suicidal ideation.


Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea,...

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References and Reading

  1. Physicians’ Desk Reference. (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.
  2. Free Drug Online and PDA Software. www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA