Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Donepezil

  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1651

Generic Name

Donepezil

Brand Name

Aricept and Aricept ODT

Class

Acetylcholinesterase inhibitors and central

Proposed Mechanism(s) of Action

Reversibly, but noncompetitively, inhibits central acetylcholinesterase, thus making more acetylcholine available at the nerve synapse.

Indication

Alzheimer’s disease

Off-Label Use

Other memory disorders or mild cognitive impairments

Side Effects

Nausea, diarrhea, insomnia, infection, headache, vomiting, cramping, fatigue, anorexia, hypertension, abnormal dreams, confusion, and syncope

Serious

Seizures and syncope (both rare)

Common

Nausea, diarrhea, weight loss, muscle cramps, fatigue, depression, and abnormal dreaming

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of Psychology, Nova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA