Proposed Mechanism(s) of Action
Desipramine acts primarily as an inhibitor of the norepinephrine reuptake pump. This results in a boost in neurotransmitter availability in the cleft and, since dopamine is inactivated by norepinephrine reuptake in the prefrontal cortex, it is hypothesized that desipramine also increases to total ambient availability of dopamine as well. At higher doses, it appears to boost presynaptic serotonin production and release.
Anxiety, insomnia, neuropathic pain, and treatment-resistant depression.
Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QT prolongation, hepatic failure, mania, and potential for activation of suicidal ideation.
Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue,...
References and Readings
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