Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Chlorpromazine

  • John C. Courtney
  • Cristy AkinsEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1637

Generic Name

Chlorpromazine

Brand Name

Thorazine

Class

Conventional antipsychotic

Proposed Mechanism(s) of Action

Blocks dopamine 2 receptors, dopamine D2, histamine H1, and cholinergic M1 blockade in the vomiting center (area postrema)

Indication

Schizophrenia, nausea, vomiting, restlessness before surgery, manic episodes of bipolar disorder, and tetanus

Off-Label Use

Bipolar disorder

Side Effects

Serious

Neuroleptic malignant syndrome, jaundice, agranulocytosis, and seizures

Common

Neuroleptic-induced deficit syndrome, akathisia, extrapyramidal symptoms, priapism, and amenorrhea

References and Readings

  1. Physicians’ desk reference (62nd ed.). (2007). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA