Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Carbamazepine

  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1635

Generic Name

Carbamazepine

Brand Name

Tegretol, Carbatrol, Equetro, Epitol, Tegretol XR, Carbamazepine Chewtabs, Carbamazepine CR, Teril, and Carnexiv

Class

Anticonvulsants, antimanic agents, and bipolar disorder agents

Proposed Mechanism(s) of Action

Carbamazepine is a use-dependent blocker of voltage-sensitive sodium channels; it interacts with the open channel conformation of voltage-sensitive sodium channels; it interacts at alpha pore-forming subunit of voltage-sensitive sodium channels, and it inhibits release of glutamate.

Indication

Complex partial seizures, generalized tonic-clonic seizures, mixed seizure patterns, bipolar mania, restless legs syndrome, postherpetic neuralgia, trigeminal neuralgia pain, and intravenous carbamazepine (Orphan).

Off-Label Use

Glossopharyngeal neuralgia, psychosis, schizophrenia, and personality disorders.

Side Effects

Serious

Aplastic anemia, agranulocytosis, Stevens-Johnson syndrome, cardiac problems, induction of psychosis or mania, and...

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References and Readings

  1. Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.
  2. Free Drug Online and PDA Software. www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA