Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1630

Generic Name

Aripiprazole, Aripiprazole lauroxil

Brand Name

Abilify, Abilify Maintena, Aristada (extended release, injectable)


Atypical neuroleptic

Proposed Mechanism(s) of Action

Partial agonism at dopamine 2 receptors. Also inhibits 5HT2a receptors, thus increasing presynaptic release of related catecholamines.


Schizophrenia, bipolar (mixed/manic), adjunctive for major depressive disorder, and autistic irritability in children and teens.

Off-Label Use

Other psychotic disorders, acute mania, bipolar maintenance, bipolar depression, behavioral disturbances associated with dementias, behavioral disturbances in children and adolescents, and impulse control disorders.

Side Effects


Neuroleptic malignant syndrome and seizures.


Insomnia, dizziness, activation, akathisia, nausea, and vomiting.

References and Readings

  1. Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com.
  2. Free Drug Online and PDA Software: www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mercy Family CenterMetarieUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA