Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1626

Generic Name


Brand Name



Tetracyclic antidepressant

Proposed Mechanism(s) of Action

Amoxapine inhibits reuptake of norepinephrine and noradrenaline. It is also known to antagonize serotonin 2A receptors, thus increasing presynaptic release of amines. Mild dopamine 2 blockade.


Depression, reactive depressive disorder, psychotic depression, and depression accompanied by anxiety or agitation.

Off-Label Use

Depressive phase of a bipolar disorder, anxiety, insomnia, neuropathic pain, and treatment-resistant depression.

Side Effects


Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, intraocular pressure, mania, and potential for activation of suicidal ideation.


Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and...

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References and Readings

  1. Physicians’ Desk Reference (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.
  2. Free Drug Online and PDA Software. www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA