Proposed Mechanism(s) of Action
Amoxapine inhibits reuptake of norepinephrine and noradrenaline. It is also known to antagonize serotonin 2A receptors, thus increasing presynaptic release of amines. Mild dopamine 2 blockade.
Depression, reactive depressive disorder, psychotic depression, and depression accompanied by anxiety or agitation.
Depressive phase of a bipolar disorder, anxiety, insomnia, neuropathic pain, and treatment-resistant depression.
Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, intraocular pressure, mania, and potential for activation of suicidal ideation.
Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and...
References and Readings
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