Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Tourette Syndrome

  • Jaeson KaylegianEmail author
  • Scott J. Hunter
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1600


Gilles de la Tourette syndrome; Tics

Short Description and Categorization

Tourette Syndrome (TS) is a childhood-onset movement disorder characterized by involuntary motor and vocal tics that may wax and wane over time. It was first reported in 1885 by Gilles de la Tourette and Jean-Martin Charcot. The pathophysiological underpinning for the symptoms of TS is commonly identified as dysfunction in basal ganglia mediated fronto-subcortical circuits (Kurlan 1994).


TS occurs in approximately 1% of the population (Hunter 2007; Robertson 2008). Common motor tics include eye blinking, head jerking, and facial grimaces. Throat clearing, sniffing, and blowing are common vocal tics. Coprolalia, a vocal tic that is characterized by use of obscene language, is present in less than 15% of individuals with TS. TS occurs more often in males than females (average male/female ratio 4:1) and has been observed across ethnic and racial groups, but is thought to occur more often in...

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References and Reading

  1. Ackermans, L., Temel, Y., et al. (2008). Deep brain stimulation in Tourette syndrome. Neurotherapeutics, 5, 339–344.PubMedCentralCrossRefPubMedGoogle Scholar
  2. Bloch, M. H., Peterson, B. S., Scahill, L., Otka, J., Katsovich, L., Zhang, H., & Lackman, J. F. (2006). Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Archives of Pediatrics and Adolescent Medicine, 160, 65–69.CrossRefGoogle Scholar
  3. Burd, L., Freeman, R. D., et al. (2005). Tourette syndrome and learning disabilities. BMC Pediatrics, 5, 34.PubMedCentralCrossRefPubMedGoogle Scholar
  4. Channon, S., Pratt, P., et al. (2003). Executive function, memory, and learning in Tourette syndrome. Neuropsychology, 17, 247–254.CrossRefGoogle Scholar
  5. Crawford, S., Channon, S., et al. (2005). Tourette syndrome: Performance on tests of behavioral inhibition, working memory and gambling. Journal of Child Psychology & Psychiatry, 46, 1327–1336.CrossRefGoogle Scholar
  6. Denckla, M. B. (2006). Attention deficit hyperactivity disorder: The childhood co-morbidity that most influences the disability burden in Tourette syndrome. Advances in Neurology, 99, 17–21.PubMedGoogle Scholar
  7. Erenberg, G. (2005). The relationship between Tourette syndrome, attention deficit hyperactivity disorder, and stimulant medication: A critical review. Seminars in Pediatric Neurology, 12, 217–221.CrossRefGoogle Scholar
  8. Gaze, C., Kepley, H. O., et al. (2006). Co-occurring psychiatric disorders in children and adolescents with Tourette syndrome. Journal of Child Neurology, 21, 657–664.CrossRefGoogle Scholar
  9. Harcherik, D. F., Leckman, J. F., Detlor, J., & Cohen, D. J. (1984). A new instrument for clinical studies of Tourette syndrome. Journal of the American Academy of Child Psychiatry, 23, 153–160.CrossRefGoogle Scholar
  10. Harrison, J. N., Schneider, B., & Walkup, J. T. (2007). Medical management of Tourette syndrome and co-occurring conditions. In D. W. Woods, J. C. Piacentini, & J. T. Walkup (Eds.), Treating Tourette syndrome and tic disorders (pp. 113–153). New York: Guilford Press.Google Scholar
  11. Himle, M. B., Woods, D. W., et al. (2006). Brief review of habit reversal training for Tourette syndrome. Journal of Child Neurology, 21, 719–725.CrossRefGoogle Scholar
  12. Hunter, S. J. (2007). Pediatric movement disorders. In S. J. Hunter & J. Donders (Eds.), Pediatric neuropsychological intervention (pp. 314–337). New York: Cambridge University Press.Google Scholar
  13. Kurlan, R. (1994). Hypothesis II: Tourette Syndrome is part of a clinical spectrum that includes normal brain development. Archives of Neurology, 51, 1145–1150.CrossRefGoogle Scholar
  14. Lavoie, M. E., Thibault, G., et al. (2007). Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. Cognitive Neuropsychiatry, 12, 165–181.PubMedCentralCrossRefPubMedGoogle Scholar
  15. Leckman, J. F. (2003). Phenomenology of tics and natural history of tic disorders. Brain and Development, 25, S24–S28.CrossRefGoogle Scholar
  16. Leckman, J. F., Riddle, M. A., Hardin, M. T., Ort, S. I., Swartz, K. L., Stevenson, J., & Cohen, D. J. (1989). The Yale global tic severity scale: Initial testing of a clinician-rated scale of tic severity. Journal of the American Academy of Child & Adolescent Psychiatry, 28, 566–573.CrossRefGoogle Scholar
  17. Osmon, D. C., & Smerz, J. M. (2005). Neuropsychological evaluation in the diagnosis and treatment of Tourette syndrome. Behavior Modification, 29, 746–783.CrossRefGoogle Scholar
  18. Peterson, B. S. (1996). Considerations of natural history and pathophysiology in the psychopharmacology of Tourette syndrome. Journal of Clinical Psychiatry, 57, 24–34.PubMedGoogle Scholar
  19. Peterson, A. L. (2007). Psychosocial management of tics and intentional repetitive behaviors associated with Tourette syndrome. In D. W. Woods, J. C. Piacentini, & J. T. Walkup (Eds.), Treating Tourette syndrome and tic disorders (pp. 154–184). New York: Guilford Press.Google Scholar
  20. Piacentini, J. C., Woods, D. W., et al. (2010). Behavior therapy for children with Tourette Syndrome: A randomized controlled trial. Journal of the American Medical Association, 303, 1929–1937.CrossRefGoogle Scholar
  21. Riddle, M. A., & Carlson, J. (2001). Clinical psychopharmacology for Tourette syndrome and associated disorders. Advances in Neurology, 85, 343–354.PubMedGoogle Scholar
  22. Robertson, M. (2008). The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: The epidemiology and prevalence studies. Journal of Psychosomatic Research, 65, 461–472.CrossRefGoogle Scholar
  23. Serajee, F. J., & Mahbubul Huq, A. H. M. (2015). Advances in Tourette syndrome diagnoses and treatment. Pediatric Clinics of North America, 62, 687–701.CrossRefGoogle Scholar
  24. Shapiro, A. K., & Shapiro, E. (1984). Controlled study of pimozide versus placebo in Tourette syndrome. Journal of the American Academy of Child & Adolescent Psychiatry, 23, 161–173.CrossRefGoogle Scholar
  25. Shprecher, D. R., Kious, B. M., & Himle, M. B. (2015). Advances in mechanistic understanding and treatment approaches to Tourette’s syndrome. Discovery Medicine, 20, 295–301.PubMedGoogle Scholar
  26. Shytle, R. D., Silver, A. A., et al. (2003). The Tourette’s Disorder Scale (TODS): Development, reliability and validity. Assessment, 10, 273–287.CrossRefGoogle Scholar
  27. Storch, E. A., Merlo, L. J., et al. (2007). Further psychometric examination of the Tourette’s disorder scales. Child Psychiatry and Human Development, 38, 89–98.CrossRefGoogle Scholar
  28. Verdellen, C. W., Keijsers, G. P., et al. (2004). Exposure with response prevention versus habit reversal in Tourette syndrome: A controlled study. Behavior Research and Therapy, 42, 501–511.CrossRefGoogle Scholar
  29. Walkup, J. T., Rosenberg, L. A., Brown, J., & Singer, H. S. (1992). The validity of instruments measuring tic severity in Tourette Syndrome. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 472–477.CrossRefGoogle Scholar
  30. Wilhelm, S., Peterson, A. L., et al. (2012). Randomized trial of behavior therapy for adults with Tourette’s disorder. Archives of General Psychiatry, 69(8), 795–803.PubMedCentralCrossRefPubMedGoogle Scholar
  31. Woods, D. W., Piacentini, J. C., & Walkup, J. T. (2007). Treating Tourette syndrome and tic disorders. New York: Guilford Press.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Departments of Psychiatry and Behavioral Neuroscience, and Pediatrics, Pediatric Neuropsychology, Section of Child and Adolescent PsychiatryThe University of ChicagoChicagoUSA
  2. 2.Neuropsychology Technician IIIUniversity of Chicago MedicineChicagoUSA