Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Pleomorphic, Pleomorphism

  • Carol L. ArmstrongEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_146


Pleomorphic changes


In neoplasms, pleomorphisms are changes that occur to neurons involved in the neoplasm, causing great changes in the size and shape of the cell and its nucleus, and bizarre cytologic features. The tumors themselves may take on a variety of shapes and sizes and can be described as pleomorphic. These changes can make the cells difficult to differentiate on pathologic examination. In general, microglial pleomorphism is a basic response to injury in other settings. Pleomorphic changes are one of the criteria in the World Health Organization criteria for tumor grading and contribute to a diagnosis of increasing malignancy.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Child and Adolescent Psychiatry and Behavioral SciencesThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA