Pilocytic Astrocytoma and Juvenile Pilocytic Astrocytoma
Reference work entry
JPA; Juvenile pilocytic astrocytoma
The pilocytic astrocytoma, or juvenile pilocytic astrocytoma, is an intracranial tumor that results from the neoplastic proliferation of astrocytes, cells that are nonneural and serve as supportive cells of the nervous system. Astrocytic tumors are categorized into pilocytic and ordinary subtypes. Ordinary astrocytomas have a worse overall prognosis than the pilocytic because of their more aggressive behavior and their potential to undergo malignant transformation. The JPA occurs predominantly in children and young adults. It is the most common astrocytic tumor in children, accounting for 80–85% of cerebellar astrocytomas and 60% of optic gliomas. It is usually located in the cerebellum, brainstem, hypothalamic region, or optic pathways and can also occur in any area where astrocytes are present, including the cerebral hemispheres and the spinal cord. It is often cystic and if solid tends to be well circumscribed. Its presenting...
References and Readings
© Springer International Publishing AG, part of Springer Nature 2018