Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Pseudobulbar Palsy

  • Mary-Ellen MeadowsEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1394


Pseudobulbar affect; Pseudobulbar paralysis; Spastic bulbar palsy

Short Description or Definition

The term “pseudobulbar palsy” is used to denote dysarthria and dysphagia caused by lesions of the upper motor neuron fibers in the corticobulbar pathways, as opposed to bulbar palsy, which is caused by lesions of the brain stem or lower motor neurons. The syndrome of pseudobulbar palsy can also be associated with pseudobulbar affect (PBA), and sometimes the two terms are used interchangeably. Lesions of descending white matter pathways can produce abnormal pseudobulbar affect and can be observed in multiple sclerosis (MS) patients and other cortical syndromes. Patients with pseudobulbar affect exhibit bouts of crying or laughter that are not associated with underlying feelings of sadness or happiness and typically occur with disruptions to corticopontine-cerebellar networks that are integral to regulating emotional expression.


The epidemiology of pseudobulbar palsy is...

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References and Readings

  1. Brooks, B. R., Crumpacker, D., Fellus, J., Kantor, D., & Kaye, R. E. (2013). PRISM: A novel research tool to assess the prevalence of pseudobulbar affect symptoms across neurological conditions. PLoS One, 8, 1–8.Google Scholar
  2. Feinstein, A. (2007). Multiple sclerosis and pseudobulbar affect. In A. Feinstein (Ed.), The clinical neuropsychiatry of multiple sclerosis (pp. 82–98). New York: Cambridge University Press.CrossRefGoogle Scholar
  3. Graham, K. C., & Speigel, D. R. (2008). Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. Journal of Neuropsychiatry & Clinical Neurosciences, 20(1), 110–111.CrossRefGoogle Scholar
  4. Kaufman, D. M. (2007). Clinical neurology for psychiatrists (6th ed.). Philadelphia: Saunders Elsevier.Google Scholar
  5. Moore, D. B., & Jefferson, J. W. (2004). Handbook of medical psychiatry (2nd ed.). Philadelphia: Mosby Elsevier.Google Scholar
  6. Moore, S., Gresham, L., Bromberg, M., Kasarkis, E., & Smith, R. (1997). A self report measure of affective lability. Journal of Neurology, Neurosurgery and Psychiatry, 63, 89–93.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Robinson, R. G., Parikh, R. M., Lipsey, J. R., Starkstein, S. E., & Price, T. R. (1993). Pseudobulbar affect following stroke: Validation of a measurement scale and double-blind treatment study. American Journal of Psychiatry, 150, 286–293.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Tateno, A., Jorge, R. E., & Robinson, R. (2004). Pathological laughing and crying following traumatic brain injury. Journal of Neuropsychiatry and Clinical Neurosciences, 16, 426–434.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Vidovic, V., Rovazdi, M. C., Kraml, O., & Kes, V. B. (2015). Pseudobulbar affect in multiple sclerosis patients. Acta Clinica Croatica, 54, 159–163.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Cognitive and Behavioral NeurologyBrigham and Women’s HospitalBostonUSA