Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Anterior Cingulate Cortex

  • Ronald A. CohenEmail author
  • Anna MacKay-Brandt
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1265




The anterior cingulate cortex (ACC) is a mesocortical paralimbic area located anterior to the corpus callosum and posterior to the prefrontal cortex. The ACC was once viewed as a single limbic structure, forming an important part of the “Papez” circuit, though in reality analysis of its cytoarchitecture indicates that it consists of regions with different cell types. Its cell characteristics are agranular and therefore are distinct from the cortex.

The ACC encompasses several Brodmann areas, including areas 24, 25, 32, and 33. The ACC wraps around the corpus callosum, having the appearance of a collar or belt. In fact, the term cingulum means belt in Latin. A large volume of the ventral ACC consists of Area 24, which merges with the posterior cingulate cortex (Area 23) along the posterior half of the corpus callosum. The division between the ACC and posterior cingulate is undifferentiated to a large extent, though these areas can be separated based on the...

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References and Readings

  1. Ballentine Jr., H. T., Levey, B. A., Dagi, T. F., & Diriunas, I. B. (1977). Neurosurgical treatment in psychiatry, pain, and epilepsy. In W. H. Sweet, S. Obrador, & J. G. Martin-Rodriques (Eds.), Cingulotomy for psychiatric illness: Report of 13 years experience (pp. 333–353). Baltimore: University Park Press.Google Scholar
  2. Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S., & Cohen, J. D. (1999). Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature, 402(6758), 179–181.PubMedCrossRefGoogle Scholar
  3. Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215–222.PubMedCrossRefGoogle Scholar
  4. Cohen, R. A., Kaplan, R. F., Meadows, M. E., & Wilkinson, H. (1994). Habituation and sensitization of the orienting response following bilateral anterior cingulotomy. Neuropsychologia, 32(5), 609–617.CrossRefGoogle Scholar
  5. Cohen, R. A., Kaplan, R. F., Zuffante, P., Moser, D. J., Jenkins, M. A., Salloway, S., et al. (1999). Alteration of intention and self-initiated action associated with bilateral anterior cingulotomy. Journal of Neuropsychiatry and Clinical Neurosciences, 11(4), 444–453.PubMedCrossRefGoogle Scholar
  6. Cohen, R. A., Paul, R., Zawacki, T. M., Moser, D. J., Sweet, L., & Wilkinson, H. (2001). Emotional and personality changes following cingulotomy. Emotion, 1(1), 38–50.PubMedCrossRefGoogle Scholar
  7. Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118(Pt. 1), 279–306.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Clinical and Health Psychology, College of Public Health and Health ProfessionsUniversity of FloridaGainesvilleUSA
  2. 2.Center for Cognitive Aging and Memory, McKnight Brain InstituteUniversity of FloridaGainesvilleUSA
  3. 3.Nathan S. Kline Institute for Psychiatric ResearchOrangeburgUSA
  4. 4.Taub Institute for Research on Alzheimer’s Disease and the Aging BrainColumbia UniversityNew YorkUSA