Late Effects of Radiation Therapy
Radiation therapy is considered a necessary treatment for many types of tumor and is frequently used in the CNS for the treatment of primary brain tumors, arteriovenous malformations, small-cell lung cancer, high-risk leukemia, brain metastases, and other neoplasms. However, there are severe iatrogenic late effects of radiotherapy (XRT), which are very significant when they occur in the context of either partial brain fields or whole brain field. Late effects are defined as those occurring after the complete dose of XRT has been administered. XRT is used as an adjunct to surgical resection of the mass, which provides the best cure or prevention of recurrence. The curative effects are not always the goal, and it is also used as prophylaxis, and as palliation, that is, to prolong life expectancy.
References and Readings
- Vigliani, M.-C., Duyckaerts, C., & Delattre, J.-Y. (1997). Radiation-induced cognitive dysfunction in adults. In C. J. Vecht (Ed.), Handbook of clinical neurology: Vol. 23(67), neuro-oncology (pp. 371–388). New York: Elsevier.Google Scholar