Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Gliomatosis Cerebri

  • Mi-Yeoung JoEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_113


Diffuse cerebral gliomatosis; Infiltrative diffuse astrocytosis


Gliomatosis cerebri is a rare type of aggressive, malignant tumor of astrocytic origin that is characterized by individual cells that diffusely infiltrate the brain with poorly circumscribed boundaries. It affects both white and gray matter in the cerebrum and can also occur in the cerebellum, brain stem, and spinal cord. It often arises in adults in their 30s or 40s and is very resistant to treatment. Gliomatosis cerebri can be difficult to distinguish from other highly aggressive tumors such as glioblastoma multiforme. Personality and mental status changes are commonly seen, particularly early on in the disease. Symptoms of raised intracranial pressure such as headaches and vomiting may be present. Other symptoms can include lethargy, seizures, visual disturbance, dementia, motor symptoms, and endocrine abnormalities. Prognosis is generally unfavorable with a relatively short survival time. Surgical...

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References and Readings

  1. Herrlinger, U., Felsberg, J., Küker, W., Bornemann, A., Plasswilm, L., Knobbe, C. B., Strik, H., Wick, W., Meyermann, R., Dichgans, J., Bamberg, M., Reifenberger, G., & Weller, M. (2002). Gliomatosis cerebri: Molecular pathology and clinical course. Annals of Neurology, 52(4), 390–399.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Sherman OaksUSA