Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Amnestic Syndromes

  • Ginette LaflecheEmail author
  • Mieke Verfaellie
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1104

Short Description or Definition

The amnestic syndromes are a group of neurologic disorders characterized by a dense global amnesia. This amnesia is comprised of an inability to form new memories (anterograde amnesia) and an inability to retrieve old memories (retrograde amnesia) (Anterograde Amnesia and Retrograde Amnesia). A unique feature of these disorders is that the dense memory loss occurs within the context of relatively preserved intelligence, language, attention, and perceptual abilities.


The amnestic syndromes can be classified according to cause or site of damage. Possible etiologies include herpes simplex encephalitis, anoxia, Wernicke-Korsakoff syndrome, cerebrovascular accidents, anterior communicating artery aneurysm (ACoA), and tumors. These disorders can give rise to amnesia by damaging any of an array of structures, such as the medial temporal lobes (including the hippocampus), the midline diencephalic nuclei, and the basal forebrain, or by disrupting...

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References and Readings

  1. Alexander, M. P., & Freedman, M. (1984). Amnesia after anterior communicating artery aneurysm rupture. Neurology, 34(6), 5–11.CrossRefGoogle Scholar
  2. Alexander, M. P., Lafleche, G., Schnyer, D., Lim, C., & Verfaellie, M. (2011). Cognitive and functional recovery after out of hospital cardiac arrest. Journal of the International Neuropsychological Society, 17, 1–5.CrossRefGoogle Scholar
  3. Caine, D., & Watson, J. D. G. (2000). Neurospsychological and neuropathological sequelae of cerebral anoxia: A critical review. Journal of the International Neuropsychological Society, 6, 86–99.PubMedCrossRefGoogle Scholar
  4. DeLuca, J., & Diamond, B. J. (1995). Aneurysm of the anterior communicating artery: A review of neuroanatomical and neuropsychological sequelae. Journal of Clinical and Experimental Neuropsychology, 17, 100–121.PubMedCrossRefGoogle Scholar
  5. DeRenzi, E., Liotti, M., & Nichelli, P. (1987). Semantic amnesia with preservation of autobiographical memory: A case report. Cortex, 23, 578–597.Google Scholar
  6. Di Paola, M., Caltagirone, C., Fadda, L., Sabatini, U., Serra, L., & Carlesimo, G. A. (2008). Hippocampal atrophy is the critical brain change in patients with hypoxic amnesia. Hippocampus, 18(7), 719–728.PubMedCrossRefGoogle Scholar
  7. Gadian, D. G., Aiardi, J., Watkins, K. E., Porter, D. A., Mishkin, M., & Vargha-Khadem, F. (2000). Developmental amnesia associated with early hypoxic-ischaemic injury. Brain, 123, 499–507.PubMedCrossRefGoogle Scholar
  8. Glisky, E. L., Schacter, D. L., & Tulving, E. (1986). Learning and retention of computer-related vocabulary in memory-induced patients: Method of vanishing cues. Journal of Clinic Journal of Clinical and Experimental Neuropsychology, 8, 292–312.CrossRefGoogle Scholar
  9. Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment. New York: Oxford University Press.Google Scholar
  10. O’Connor, M. G., Butters, N., Miliotis, P., Eslinger, P., & Cermak, L. S. (1992). The dissociation of anterograde and retrograde amnesia in a patient with herpes simplex encephalitis. Journal of Clinical and Experimental Neuropsychology, 14, 159–178.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Rempel-Clower, N. L., Zola, S. M., Squire, L. R., & Amaral, D. (1996). Three cases of enduring memory impairment after damage limited to the hippocampal formation. The Journal of Neuroscience, 16(16), 5233–5255.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Stefanacci, L., Buffalo, E. A., Schmolck, H., & Squire, L. R. (2000). Profound amnesia after damage to the medial temporal lobe: A neuroanatomical and neuropsychological profile of patient EP. The Journal of Neuroscience, 20, 7024–7036.PubMedCrossRefGoogle Scholar
  13. Van der Werf, Y. D., Witter, M. P., Uylings, H. B., & Jolles, J. (2000). Neuropsychology of infarctions in the thalamus: A review. Neuropsychologia, 38, 613–627.PubMedCrossRefGoogle Scholar
  14. Vargha-Khadem, F., Gadian, D. G., & Mishkin, M. (2001). Dissociations in cognitive memory: The syndrome of developmental amnesia. Philosophical Transactions of the Royal Society of London B, 356, 1435–1440.CrossRefGoogle Scholar
  15. Von Cramon, D., Hebel, N., & Schuri, U. (1988). Verbal memory and learning in unilateral posterior cerebral infarction. Brain, 111, 1061–1077.CrossRefGoogle Scholar
  16. Warrington, E. K., & Shallice, T. (1984). Category specific semantic impairments. Brain, 107, 829–854.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Zola-Morgan, S., Squire, L. R., & Amaral, D. G. (1986). Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA 1 of the hippocampus. The Journal of Neuroscience, 6(10), 2950–2967.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of MedicineBostonUSA