Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Endothelial Proliferation

  • Carol L. ArmstrongEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_106


Vascular endothelial proliferation


Endothelial proliferation is an increase in vascular endothelial cells needed for the growth of new or existing blood vessels. It is stimulated by solid tumors that need to generate blood vessels to continue growth. It contributes to angiogenesis in tumor formation (Louis and Cavenee 2005) and results from overexpression of vascular endothelial growth factor (VEGF). Endothelial proliferation is one of the characteristics of malignancy in gliomas as defined by the World Health Organization’s primary central nervous system tumor grading system (Kleihues et al. 1993). Endothelial proliferation is associated with breakdown in the blood-brain barrier (Kracht et al. 2004). It is a feature of malignancy that indicates poor prognosis but is considered in combination with other features such as genetic markers that predict tumor growth.

References and Readings

  1. Kleihues, P., Burger, P. C., & Scheithauer, B. W. (1993). The new WHO classification of brain tumours. Brain Pathology, 3(3), 255–268.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Kracht, L. W., Miletic, H., Busch, S., Jacobs, A. H., Voges, J., Hoevels, M., et al. (2004). Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: Local comparison with stereotactic histopathology. Clinical Cancer Research, 10, 7163–7170.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Louis, D. N., & Cavenee, W. K. (2005). Molecular biology of central nervous system tumors. Boston: Massachusetts General Hospital, MGH Neurosurgical Service, Brain Tumor Center. http://brain.mgh.harvard.edu/MolecularGenetics.htm.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Child and Adolescent Psychiatry and Behavioral SciencesThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA