Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Interictal Behavior Syndrome

  • Nuri Erkut KucukboyaciEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1046


Geschwind syndrome (or Waxman-Geschwind Syndrome); Interictal personality syndrome; Temporal lobe syndrome


A distinct behavioral presentation described initially by Stephen Waxman and Norman Geschwind that occurs interictally (i.e., between seizure events) in some patients with complex partial seizures with involvement of the temporal lobes. It presents as personality changes that are concomitant with abnormal EEG activity in limbic regions and is more often associated with individuals with left temporal lobe epilepsy. These changes have been described to include alterations in sexual behavior (usually decreased interest in sexual behavior), increased religiosity (hyper-religiosity and/or hyper-morality), increased verbal output, tendency towards extensive, compulsive writing (i.e., hypergraphia), circumstantial thinking, stickiness or viscosity in thinking and social interactions, and deepened emotionality.

Current Knowledge

This term dates back to earlier times in...

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References and Readings

  1. Bear, D. M., & Fedio, P. (1977). Quantitative analysis of interictal behavior in temporal lobe epilepsy. Archives of Neurology, 34(8), 454–467.PubMedCrossRefGoogle Scholar
  2. Blumer, D. (1999). Evidence supporting the temporal lobe epilepsy personality syndrome. Neurology, 53(Suppl. 2), S9–S12.PubMedGoogle Scholar
  3. Broicher, S. D., Kuchukhidze, G., Grunwald, T., Krämer, G., Kurthen, M., & Jokeit, H. (2012). “Tell me how do I feel” – Emotion recognition and theory of mind in symptomatic mesial temporal lobe epilepsy. Neuropsychologia, 50(1), 118–128.  https://doi.org/10.1016/j.neuropsychologia.2011.11.005. ISSN: 0028-3932.CrossRefPubMedGoogle Scholar
  4. Devinsky, O., & Najjar, S. (1999). Evidence against the existence of a temporal lobe epilepsy personality syndrome. Neurology, 53(Suppl. 2), S13–S25.PubMedGoogle Scholar
  5. Trimble, M., & Freeman, A. (2006). An investigation of religiosity and the Gastaut-Geschwind syndrome in patients with temporal lobe epilepsy. Epilepsy and Behavior, 9(3), 407–414. Epub 2006 Aug 17.PubMedCrossRefGoogle Scholar
  6. van Elst, L. T., Krishnamoorthy, E. S., Bäumer, D., Selai, C., von Gunten, A., Gene-Cos, N., Ebert, D., & Trimble, M. R. (2003). Psychopathological profile in patients with severe bilateral hippocampal atrophy and temporal lobe epilepsy: Evidence in support of the Geschwind syndrome? Epilepsy and Behavior, 4(3), 291–297.PubMedCrossRefGoogle Scholar
  7. Waxman, S. G., & Geschwind, N. (1975). The interictal behavior syndrome of temporal lobe epilepsy. Archives of General Psychiatry, 32(12), 1580–1586.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Clinical PsychologyRusk Institute - NYU Langone HealthNew YorkUSA