Vortioxetine
Living reference work entry
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DOI: https://doi.org/10.1007/978-3-319-56782-2_9270-1
Generic Name
Vortioxetine
Brand Name
Trintellix
Class
Antidepressants, other
Proposed Mechanism(s) of Action
Enhancement of serotonergic activity in the CNS through inhibition of the reuptake of serotonin (5-HT). It also has several other activities including 5-HT3 receptor antagonism and 5-HT1A receptor agonism.
Indication
Major depressive disorder.
Off-Label Use
Neuropathic pain, chronic pain, generalized anxiety disorder, stress urinary incontinence, and fibromyalgia.
Side Effects
Serious
Seizures; hypomania; increased suicidal ideation, attempts, and completion; hyponatremia (SIAH).
Common
Nausea, diarrhea, dry mouth, constipation, vomiting, abnormal dreams, dizziness, weight gain.
References and Readings
- Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
- Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar
Additional Information
- Drug Molecule Images. http://www.worldofmolecules.com/drugs/
- Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
- Free Drug Online and PDA Software. www.epocrates.com
- Free Drug Online and PDA Software. www.medscape.com
- Free Drug Online and PDA Software. www.medscapepsychiatry.com
- Free Drug Online: CenterWatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1288/brintellix-vortioxetine
- Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList
- Jain, R., Mahableshwarkar, A. R., Jacobsen, P. L., Chen, Y., & Thase, M. E. (2013). A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder. The International Journal of Neuropsychopharmacology, 16(2), 313–321.CrossRefPubMedGoogle Scholar
- Pill Identification. http://www.drugs.com/pill_identification.html
Copyright information
© Springer International Publishing AG 2018