Binswanger’s disease (BD) is a type of subcortical vascular dementia caused by widespread, microscopic damage to cerebral white matter. The damage is usually the result of atherosclerosis (i.e., narrowing of arterial blood vessels) that reduces the supply of blood to subcortical areas of the brain, causing tissue to die. The characteristic pattern of BD-damaged brain tissue can be seen using brain imaging techniques such as computed tomography (CT) or magnetic resonance imaging (MRI). CT imaging of BD often reveals symmetric, noncontrasting hypodensities also called “leukoaraiosis,” and more sensitive MRI imaging reveals diffuse white matter lesions and scattered multiple lacunes (Akiguchi et al. 2014).
There is some controversy in the literature about whether BD constitutes a distinct clinical entity or simply describes the result of different neuropathologies that...
References and Readings
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