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Selegiline for Treating Parkinson’s Disease

  • Peter RiedererEmail author
  • Thomas Müller
Living reference work entry

Abstract

Biogenic amine turnover employs the enzymes catechol-O-methyltransferase and monoamine oxidase in neuronal and glial cells. Inhibition of these enzymes elevates biogenic amine levels in the synaptic cleft. Selegiline is a selective, irreversible monoamine oxidase-B inhibitor. Its gastrointestinal absorption is fast, the maximum concentration is reached within 1 h. Main metabolites of selegiline are desmethylselegiline, methamphetamine and L-amphetamine. Symptomatic benefits of selegiline on motor symptoms in patients with Parkinson’s disease are weak. Intervals and severity of off-periods reduce after addition of selegiline, in particular during chronic levodopa intake. Selegiline increases life expectancy in levodopa-treated patients. Selegiline is administered once or twice daily, in 5 mg tablets up to 10 mg, mostly 7.5 mg. Selegiline long-term trials demonstrate, in summary, that combination of selegiline and levodopa may provide a greater clinical benefit and less progression than levodopa alone, even when levodopa without selegiline is taken at substantially higher doses.

Keywords

Monoamine oxidase Selegiline Depression Oxidative stress Antidepressants 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Center of Mental HealthDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital WürzburgWürzburgGermany
  2. 2.Department of NeurologySt. Joseph Hospital Berlin-WeißenseeBerlinGermany

Section editors and affiliations

  • Toshiharu Nagatsu
    • 1
    • 2
  • Akira Nakashima
    • 3
  1. 1.Fujita Health University School of MedicineToyoakeJapan
  2. 2.Institute of Environmental MedicineNagoya UniversityNagoyaJapan
  3. 3.Department of Physiological ChemistryFujita Health University School of MedicineToyoake, AichiJapan

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