Parkinsonian Drugs: Indications

  • Wolfgang H. JostEmail author
Living reference work entry


Many substance classes have been introduced for the treatment of motor symptoms in Parkinson’s disease within the last 50 years. The most important and effective medication is still levodopa in combination with a decarboxylase inhibitor. In addition, dopamine agonists, monoamine oxidase B (MAO-B) inhibitors, catechol-o-methyltransferase (COMT) inhibitors, amantadine (N-methyl-d-aspartate-antagonist), and less important anticholinergics are administered depending on the motor symptoms, age, and a multitude of other factors. Fortunately, within the substance classes there are various preparations, which also have different effects. In order that the advantages of the individual medications can be exploited and undesired effects and interactions can be avoided, one must come to terms with the complex data and the pharmacology of the medication. In addition, important aspects are interactions and reciprocal actions. The decision as to which medication to choose must be made individually for each patient.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Parkinson-Klinik OrtenauWolfachGermany

Section editors and affiliations

  • Toshiharu Nagatsu
    • 1
    • 2
  • Akira Nakashima
    • 3
  1. 1.Fujita Health University School of MedicineToyoakeJapan
  2. 2.Institute of Environmental MedicineNagoya UniversityNagoyaJapan
  3. 3.Department of Physiological ChemistryFujita Health University School of MedicineToyoake, AichiJapan

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