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Gestational Betaine, Liver Metabolism, and Epigenetics

  • Demin Cai
  • Haoyu Liu
  • Yun Hu
  • Yuqian Jiang
  • Ruqian ZhaoEmail author
Reference work entry

Abstract

Betaine is a methyl donor and a substrate of methionine metabolism. It can donate methyl groups to most of methylation reactions in vivo. Diet low in betaine may greatly contribute to metabolic syndrome, lipid disorders, and diabetes. Recent research studies in the field of metabolic programming have demonstrated that betaine plays critical roles in fetal development and hepatic glucolipid metabolism via an array of complex mechanisms. Liver is a central metabolic organ, which is essential in the control of hepatic glucose, lipid, and cholesterol contents in order to maintain metabolic homeostasis in the whole body. The status of hepatic glucolipid metabolism at newborn stage will eventually affect adult health in a long term. Maternal nutrition programs neonatal hepatic metabolism through epigenetic mechanisms such as DNA methylation, histone modifications, and miRNA-mediated post-transcriptional regulation. Betaine is of critical value in maternal nutritional programming. In this chapter, we provide an overview of the recent advances in studies on the role of maternal betaine on offspring hepatic lipid and glucose metabolism, especially during early life. We hope that this knowledge may shed lights on identifying novel prophylactic and therapeutic strategies for metabolic disorders involving disrupted glucose and lipid homeostasis in human and animals.

Keywords

Betaine Maternal diet Metabolism Lipid Glucose Cholesterol Metabolic programming Epigenetic Methylation Methionine Histone modification Micro-RNAs 

List of Abbreviations

ACC

Acetyl-CoA Carboxylase

AHCY

S-adenosylhomocysteine hydrolase

BHMT

Betaine homocysteine methyltransferase

CYP27α1

Cholesterol-27alpha-hydroxylase

CYP7α1

Cholesterol-7alpha-hydroxylase

DNMTs

DNA (cytosine-5-)-methyltransferases

FAS

Fatty acid synthase

FBP1

Fructose-1, 6-bisphosphatase

G6PC

Glucose-6-phosphatase

GNMT

Glycine N-methyltransferase

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

HMTs

Histone methyltransferases

HPT

Hypothalamic-pituitary-thyroid

LDLR

Low-density lipoprotein receptor

MAT

Methionine adenosyltransferase

PC

Pyruvate carboxylase

PEPCK

Phosphoenolpyruvate carboxykinase

SAH

S-adenosylhomocysteine

SAM

S-adenosylmethionine

SCD

Stearoyl-CoA desaturase

SR-BI

High-density lipoprotein receptor

SREBP1C

Sterol regulatory element-binding protein-1c

SREBP2

Sterol regulatory element binding protein-2

TG

Triglyceride

USF

Upstream stimulating factor

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Demin Cai
    • 1
  • Haoyu Liu
    • 2
  • Yun Hu
    • 1
  • Yuqian Jiang
    • 3
  • Ruqian Zhao
    • 1
    Email author
  1. 1.Key Laboratory of Animal Physiology and Biochemistry, Ministry of AgricultureCollege of Veterinary Medicine, Nanjing Agricultural UniversityNanjingChina
  2. 2.Department of Medical Cell BiologyUppsala UniversityUppsalaSweden
  3. 3.Department of Biochemistry and Molecular MedicineUniversity of California at DavisSacramentoUSA

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