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The Methyl-CpG-Binding Domain (MBD) Protein Family: An Overview and Dietary Influences

  • Carolina Oliveira Gigek
  • Elizabeth Suchi Chen
  • Gaspar Jesus Lopes-Filho
  • Marilia Arruda Cardoso Smith
Reference work entry

Abstract

The machinery involved in controlling gene expression via DNA methylation includes DNA methyltransferases and seven methyl-CpG-binding domain (MBD) proteins. By binding to methyl-CpG marks, the MBD proteins can recruit the correct epigenetic machinery to read and to interpret the epigenetic landscape. The MBD family comprises seven proteins: MeCP2 and the MBD1–6, each one with a main function and specific characteristics. The family grouping characteristic is the conserved methyl-binding domain sequence that can recognize a single CpG. Dietary intake contributes to the epigenetic equilibrium by preventing or promoting DNA methylation and influencing epigenetic machinery proteins; expression of transgenerational effects of epigenetic marks and regulators is also addressed.

Keywords

DNA methylation MeCP2 MBD1 MBD2 MBD3 MBD4 MBD5 MBD6 Methionine Choline Folate High fat Transgenerational epigenetics Offspring 

List of Abbreviations

BAZ2A

Bromodomain adjacent to zinc finger domain 2A

BAZ2B

Bromodomain adjacent to zinc finger domain 2B

BR

Black raspberries

BRCA1

Breast cancer 1 gene

CpG

5′-Citosine–phosphate–Guanine–3′

DNA

Deoxyribonucleic acid

DNMT

DNA methyltransferases

Glut4

Glucose transporter gene

HAT

Histone acetyltransferases

HDAC

Histone deacetylases

HDM

Histone demethylases

HF

High fat

HMT

Histone methyltransferases

ICR

Imprinting control region

MBD

Methyl-CpG-binding domain

MeCP2

Methyl-CpG-binding protein 2

miRNA

MicroRNAs

mRNA

Messenger ribonucleic acid

NuRD

Nucleosome remodeling and histone deacetylase

RefSeq

Reference sequence database

RING

Really interesting new gene

SET

Suppressor of variegation 3–9, enhancer of zeste, and trithorax group

SETDB1

SET domain bifurcated 1

SETDB2

SET domain bifurcated 1

SRA

SET and RING finger-associated domain

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carolina Oliveira Gigek
    • 1
    • 2
  • Elizabeth Suchi Chen
    • 1
  • Gaspar Jesus Lopes-Filho
    • 2
  • Marilia Arruda Cardoso Smith
    • 1
  1. 1.Division of Genetics, Department of Morphology and GeneticsUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil
  2. 2.Division of Surgical Gastroenterology, Department of SurgeryUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil

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