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Modulatory Role of Curcumin in miR-Mediated Regulation in Cancer and Non-cancer Diseases

  • Sayantani Chowdhury
  • Jyotirmoy Ghosh
  • Parames C. SilEmail author
Reference work entry

Abstract

The dietary polyphenol curcumin imparts its pharmacological effects through anticancer, anti-inflammatory, antioxidant, and other mechanisms by inhibiting/modulating aberrant signaling molecules and transcription factors. MicroRNAs (miRs) modulate gene expression by regulating the degradation or translation repression of mRNA. The plethora of evidences over the past few years reflect the disruption of several fundamental regulatory mechanisms, such as carcinogenesis, cell proliferation, differentiation, programed cell death, angiogenesis, migration, invasion, etc., concerning miRs. Curcumin-mediated epigenetic alterations are the regulation of the expression of various pathogenic miRs in liver fibrosis, neurodegenerative diseases, diabetic nephropathy, ocular diseases, etc., on one hand and modulation of several tumor suppressor and oncogenic and epithelial-mesenchymal transition-suppressor microRNAs on the other hand. Based on recent evidences, miRs from miR-21, miR-26, miR-27, miR-28, miR-143, miR-199, miR-200 family, the let-7 family, etc., contribute to anomalies in both cancer and non-cancer diseases through aberrant signaling, tumor formation, and chemoresistance. In context to the significant role of miR homeostasis we summarize, in this book chapter, the findings based on in vitro and in vivo evidences on the regulatory role of curcumin on miR expression involved in cancer and non-cancer diseases.

Keywords

Curcumin Epigenetics miR Cancer Non-cancer diseases 

List of Abbreviations

Akt/mTOR signaling

Protein kinase B (PKB), also known as Akt, is a serine-/threonine-specific protein kinase/mechanistic target of rapamycin signaling

AOF1/2

Amine oxidase domain-containing protein 1/2

ARPE-19 cells

Human retinal pigment epithelial cell line

BAG2

BAG family molecular chaperone regulator 2

BMI1

B lymphoma Mo-MLV insertion region 1 homolog

CAM

Chick chorioallantoic membrane

CDKN1A

Cyclin-dependent kinase inhibitor 1A

COL1A1

Collagen type I alpha 1 chain

COX2

Cyclooxygenase-2

CML xenograft

Chronic myeloid leukemia xenograft

DNMT3b

DNA (cytosine-5-)-methyltransferase 3 beta

Dkk-3/SMAD4

DKK3; dickkopf WNT signaling pathway inhibitor 3/SMAD family member n°4

2D–DIGE

Two-dimensional difference gel electrophoresis

DNMT1

DNA (cytosine-5)-methyltransferase 1

DU145 cell

Human Caucasian prostate cell; derived from metastatic site: brain

EMT-suppressive miRs

Epithelial-mesenchymal transition-suppressive microRNAs

EZH2

Enhancer of zeste 2 polycomb repressive complex 2 subunit

Erbb3

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

HCT116 cell

Colon cancer cell line

HCT116-5FUR cell

5-fluorouracil-resistant cellosaurus cell line

HL-60 cell

Human promyelocytic leukemia cell

HAG cells

Human astroglial cells

HSC cells

Hematopoietic stem cells

HNG cells

Human neuronal glial cells

HUVECs

Human umbilical vein endothelial cells

IL-1β

Interleukin-1 beta

K562 cell

Chronic myelogenous leukemia cell

LAMA84 cell

Human leukocytic cell line

Let-7 family miRs

Lethal-7 family microRNAs

mRNA

Messenger RNA

MMP13

Matrix metallopeptidase 13

MAPK signaling

Mitogen-activated protein kinase signaling

MMP-9

Matrix metallopeptidase 9

mmu-miR

Mus musculus microRNA

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells

NKAP

NF-kappa-B-activating protein

Oct4

Octamer-binding transcription factor 4

PTEN

Phosphatase and tensin homolog

PTP1B protein

Protein-tyrosine phosphatase 1B protein

PDGFβ

Platelet-derived growth factor beta

PKCs

Protein kinase, catalytic subunit

PDCD4

Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)

PRCs

Polycomb repressive complexes

PI3K

Phosphoinositide 3-kinase

PC cells

Prostate cancer cell

Rko cell

Rectal carcinoma cell line

SCID mice

Severe combined immunodeficient mice

Sox2

SRY (sex determining region Y)-box 2

Sema6a protein

Semaphorin 6A protein

STAT-3

Signal transducer and activator of transcription 3

SUZ12

SUZ12 Polycomb repressive complex 2 subunit

SW480-5FUR cell

5-fluorouracil-resistant cellosaurus cell line

Sp proteins

Surfactant proteins

TIMP-1

Tissue inhibitors of metalloproteinases

TGIF

TG-interacting factor

TGF-β

Transforming growth factor beta

Trps1

Transcriptional repressor GATA binding 1

VEGF

Vascular endothelial growth factor

VEGFR2

Vascular endothelial growth factor receptor 2

VEGFB gene

Vascular endothelial growth factor B gene

WT1 gene

Wilms tumor 1 gene

ZBTB10

Zinc finger and BTB domain-containing 10

ZBTB4

Zinc finger and BTB domain-containing 4

Y79 RB cell

Human Caucasian retinoblastoma cell line

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sayantani Chowdhury
    • 1
  • Jyotirmoy Ghosh
    • 2
  • Parames C. Sil
    • 1
  1. 1.Division of Molecular MedicineBose InstituteKolkataIndia
  2. 2.Department of ChemistryBanwarilal Bhalotia CollegeUshagram AsansolIndia

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