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Application of Lipid Nanocarriers for the Food Industry

  • Zahra Rafiee
  • Seid Mahdi Jafari
Living reference work entry
Part of the Reference Series in Phytochemistry book series (RSP)

Abstract

Bioactive compounds effectively contribute to human health, and hence, they have recently attracted great attention in order to fortify food products and develop novel functional foods. However, employment of bioactive compounds in food matrices has some limitations. Most of the bioactive substances are readily decomposed in food as well as within the gastrointestinal tract that cause remarkable losses in their efficiency. Furthermore, they display low water solubility, poor bioavailability, and insufficient dispersibility. Other problems are related to their interaction with food ingredients and unfavorable effects on sensory attributes of food products. Lipid-formulation nanoencapsulation technologies including nanoliposomes, nanoemulsions, lipid nanoparticles (SLNs, solid lipid nanoparticles, and NLCs, nanostructured lipid carriers), and nano-phytosomes potentially help to solve these issues. These nanodelivery systems provide more stability, solubility in different media, functionality, bioavailability, targeting properties, and the ability of controlled release in food and pharmaceutical practices. This chapter reviews lipid-based nanocarriers in terms of production methods, types, characteristics, and composition for incorporation of different bioactive compounds. Also, food applications of various bioactive compounds incorporated in the commonly used lipid-based nanocarriers are highlighted. In this sense, the relevant recent studies have been discussed.

Keywords

Bioactive compounds Nanoencapsualtion Lipid-based nanocarriers Functional foods Food applications 

Reference

  1. 1.
    Abaee A, Mohammadian M, Jafari SM (2017) Whey and soy protein-based hydrogels and nano-hydrogels as bioactive delivery systems. Trends Food Sci Technol 70:69–81CrossRefGoogle Scholar
  2. 2.
    Aditya N, Macedo AS, Doktorovova S, Souto EB, Kim S, Chang P-S, Ko S (2014) Development and evaluation of lipid nanocarriers for quercetin delivery: a comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE). LWT Food Sci Technol 59:115–121CrossRefGoogle Scholar
  3. 3.
    Aditya N, Shim M, Lee I, Lee Y, Im M-H, Ko S (2013) Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity. J Agric Food Chem 61:1878–1883PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Akbarzadeh A et al (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8:102PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Akhavan S, Jafari SM (2017) Chapter 6: Nanoencapsulation of natural food colorants. In: Nanoencapsulation of food bioactive ingredients. Academic Press, London, pp 223–260CrossRefGoogle Scholar
  6. 6.
    Akhavan S, Assadpour E, Katouzian I, Jafari SM (2018) Lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals. Trends Food Sci Technol 74:132–146CrossRefGoogle Scholar
  7. 7.
    Alexander A, Patel RJ, Saraf S, Saraf S (2016) Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives. J Control Release 241:110–124PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Alexander M, Lopez AA, Fang Y, Corredig M (2012) Incorporation of phytosterols in soy phospholipids nanoliposomes: encapsulation efficiency and stability. LWT Food Sci Technol 47:427–436CrossRefGoogle Scholar
  9. 9.
    Anton N, Benoit J-P, Saulnier P (2008) Design and production of nanoparticles formulated from nano-emulsion templates – a review. J Control Release 128:185–199PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Artiga-Artigas M, Guerra-Rosas M, Morales-Castro J, Salvia-Trujillo L, Martín-Belloso O (2018) Influence of essential oils and pectin on nanoemulsion formulation: a ternary phase experimental approach. Food Hydrocoll 81:209–219CrossRefGoogle Scholar
  11. 11.
    Assadpour E, Maghsoudlou Y, Jafari S-M, Ghorbani M, Aalami M (2016a) Evaluation of folic acid Nano-encapsulation by double emulsions. Food Bioprocess Technol 9:2024–2032CrossRefGoogle Scholar
  12. 12.
    Assadpour E, Maghsoudlou Y, Jafari S-M, Ghorbani M, Aalami M (2016b) Optimization of folic acid nano-emulsification and encapsulation by maltodextrin-whey protein double emulsions. Int J Biol Macromol 86:197–207PubMedCrossRefGoogle Scholar
  13. 13.
    Assadpour E, Jafari SM, Esfanjani AF (2017) Protection of phenolic compounds within nanocarriers. CAB Rev 12:1–8CrossRefGoogle Scholar
  14. 14.
    Assadpour E, Jafari SM (2018) A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers. Crit Rev Food Sci Nutr:1–47.  https://doi.org/10.1080/10408398.2018.1484687
  15. 15.
    Babazadeh A, Ghanbarzadeh B, Hamishehkar H (2016) Novel nanostructured lipid carriers as a promising food grade delivery system for rutin. J Funct Foods 26:167–175CrossRefGoogle Scholar
  16. 16.
    Babazadeh A, Ghanbarzadeh B, Hamishehkar H (2017) Phosphatidylcholine-rutin complex as a potential nanocarrier for food applications. J Funct Foods 33:134–141CrossRefGoogle Scholar
  17. 17.
    Bagherpour S, Alizadeh A, Ghanbarzadeh S, Mohammadi M, Hamishehkar H (2017) Preparation and characterization of Betasitosterol-loaded nanostructured lipid carriers for butter enrichment. Food Biosci 20:51–55CrossRefGoogle Scholar
  18. 18.
    Balta I, Brinzan L, Stratakos AC, Linton M, Kelly C, Pinkerton L, Corcionivoschi N (2017) Geraniol and linalool loaded Nanoemulsions and their antimicrobial activity bulletin UASVM. Animal Sci Biotechnol 74:2Google Scholar
  19. 19.
    Bhosale AP, Patil A, Swami M (2015) Herbosomes as a novel drug delivery system for absorption enhancement. World J Pharmacy Pharmaceut Sci 5:345–355Google Scholar
  20. 20.
    Bochicchio S, Barba AA, Grassi G, Lamberti G (2016) Vitamin delivery: carriers based on nanoliposomes produced via ultrasonic irradiation. LWT Food Sci Technol 69:9–16CrossRefGoogle Scholar
  21. 21.
    Bose S, Du Y, Takhistov P, Michniak-Kohn B (2013) Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Int J Pharm 441:56–66PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Bou R, Cofrades S, Jiménez-Colmenero F (2014) Physicochemical properties and riboflavin encapsulation in double emulsions with different lipid sources. LWT Food Sci Technol 59:621–628CrossRefGoogle Scholar
  23. 23.
    Bouksaim M, Lacroix C, Audet P, Simard R (2000) Effects of mixed starter composition on nisin Z production by Lactococcus lactis subsp. lactis biovar. Diacetylactis UL 719 during production and ripening of gouda cheese. Int J Food Microbiol 59:141–156PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Caddeo C, Teskač K, Sinico C, Kristl J (2008) Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells. Int J Pharm 363:183–191PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Cadena PG et al (2013) Nanoencapsulation of quercetin and resveratrol into elastic liposomes. Biochimica et Biophysica Acta (BBA)-Biomembranes 1828:309–316CrossRefGoogle Scholar
  26. 26.
    Campani V, Biondi M, Mayol L, Cilurzo F, Pitaro M, De Rosa G (2016) Development of nanoemulsions for topical delivery of vitamin K1. Int J Pharm 511:170–177PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Cavazos-Garduño A, Flores AO, Serrano-Niño J, Martínez-Sanchez C, Beristain C, García H (2015) Preparation of betulinic acid nanoemulsions stabilized by ω-3 enriched phosphatidylcholine. Ultrason Sonochem 24:204–213PubMedCrossRefPubMedCentralGoogle Scholar
  28. 28.
    Chen C, Han D, Cai C, Tang X (2010) An overview of liposome lyophilization and its future potential. J Control Release 142:299–311PubMedCrossRefPubMedCentralGoogle Scholar
  29. 29.
    Chen F, Liang L, Zhang Z, Deng Z, Decker EA, McClements DJ (2017) Inhibition of lipid oxidation in nanoemulsions and filled microgels fortified with omega-3 fatty acids using casein as a natural antioxidant. Food Hydrocoll 63:240–248CrossRefGoogle Scholar
  30. 30.
    Chen H, Weiss J, Shahidi F (2006) Nanotechnology in nutraceuticals and functional foods. Food Technol 03.06(3):30–36Google Scholar
  31. 31.
    Chen X, Zou L-Q, Niu J, Liu W, Peng S-F, Liu C-M (2015) The stability, sustained release and cellular antioxidant activity of curcumin nanoliposomes. Molecules 20:14293–14311PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Cho JS, Seo YC, Yim TB, Lee HY (2013) Effect of nanoencapsulated vitamin B1 derivative on inhibition of both mycelial growth and spore germination of fusarium oxysporum f. Sp.raphani. Int J Mol Sci 14:4283–4297PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Chuesiang P, Siripatrawan U, Sanguandeekul R, McLandsborough L, McClements DJ (2018) Optimization of cinnamon oil nanoemulsions using phase inversion temperature method: impact of oil phase composition and surfactant concentration. J Colloid Interface Sci 514:208–216PubMedCrossRefGoogle Scholar
  34. 34.
    Colas J-C, Shi W, Rao VM, Omri A, Mozafari MR, Singh H (2007) Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting. Micron 38:841–847PubMedCrossRefGoogle Scholar
  35. 35.
    Couto R, Alvarez V, Temelli F (2017) Encapsulation of vitamin B2 in solid lipid nanoparticles using supercritical CO2. J Supercrit Fluids 120:432–442CrossRefGoogle Scholar
  36. 36.
    Cui H, Zhao C, Lin L (2015) The specific antibacterial activity of liposome-encapsulated clove oil and its application in tofu. Food Control 56:128–134CrossRefGoogle Scholar
  37. 37.
    Cuomo F, Cofelice M, Venditti F, Ceglie A, Miguel M, Lindman B, Lopez F (2018) In-vitro digestion of curcumin loaded chitosan-coated liposomes. Colloids Surf B: Biointerfaces 168:29–34Google Scholar
  38. 38.
    Cuomo J et al (2011) Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 74:664–669PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    da Silva BV, Barreira JC, Oliveira MBP (2016) Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Trends Food Sci Technol 50:144–158CrossRefGoogle Scholar
  40. 40.
    Das S, Chaudhury A (2011) Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 12:62–76PubMedCrossRefGoogle Scholar
  41. 41.
    Dasgupta N, Ranjan S, Mundra S, Ramalingam C, Kumar A (2016) Fabrication of food grade vitamin E nanoemulsion by low energy approach, characterization and its application. Int J Food Prop 19:700–708CrossRefGoogle Scholar
  42. 42.
    Davidov-Pardo G, McClements DJ (2015) Nutraceutical delivery systems: resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification. Food Chem 167:205–212PubMedCrossRefGoogle Scholar
  43. 43.
    de Souza Simões L, Madalena DA, Pinheiro AC, Teixeira JA, Vicente AA, Ramos ÓL (2017) Micro-and nano bio-based delivery systems for food applications: in vitro behavior. Adv Colloid Interf Sci 243:23–45CrossRefGoogle Scholar
  44. 44.
    DiNicolantonio JJ, Lucan SC, O’Keefe JH (2016) The evidence for saturated fat and for sugar related to coronary heart disease. Prog Cardiovasc Dis 58:464–472PubMedCrossRefGoogle Scholar
  45. 45.
    Donsì F, Ferrari G (2016) Essential oil nanoemulsions as antimicrobial agents in food. J Biotechnol 233:106–120PubMedCrossRefGoogle Scholar
  46. 46.
    Donsì F, Sessa M, Mediouni H, Mgaidi A, Ferrari G (2011) Encapsulation of bioactive compounds in nanoemulsion-based delivery systems. Procedia Food Sci 1:1666–1671CrossRefGoogle Scholar
  47. 47.
    Emami S, Azadmard-Damirchi S, Peighambardoust SH, Valizadeh H, Hesari J (2016) Liposomes as carrier vehicles for functional compounds in food sector. J Exp Nanosci 11:737–759CrossRefGoogle Scholar
  48. 48.
    Ezhilarasi P, Karthik P, Chhanwal N, Anandharamakrishnan C (2013) Nanoencapsulation techniques for food bioactive components: a review. Food Bioprocess Technol 6:628–647CrossRefGoogle Scholar
  49. 49.
    Fang C-L, Al-Suwayeh S, Fang J-Y (2013) Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent Pat Nanotechnol 7:41–55PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Fang J-Y, Fang C-L, Liu C-H, Su Y-H (2008) Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm 70:633–640PubMedCrossRefGoogle Scholar
  51. 51.
    Fang Z, Bhandari B (2010) Encapsulation of polyphenols–a review. Trends Food Sci Technol 21:510–523CrossRefGoogle Scholar
  52. 52.
    Faridi Esfanjani A, Jafari SM (2016) Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds. Colloids Surf B: Biointerfaces 146:532–543PubMedCrossRefGoogle Scholar
  53. 53.
    Faridi Esfanjani A, Assadpour E, Jafari SM (2018) Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers. Trends Food Sci Technol 76:56–66CrossRefGoogle Scholar
  54. 54.
    Fathi M, Mozafari M-R, Mohebbi M (2012) Nanoencapsulation of food ingredients using lipid based delivery systems. Trends Food Sci Technol 23:13–27CrossRefGoogle Scholar
  55. 55.
    Fathi M, Varshosaz J (2013) Novel hesperetin loaded nanocarriers for food fortification: production and characterization. J Funct Foods 5:1382–1391CrossRefGoogle Scholar
  56. 56.
    Fathima SJ, Fathima I, Abhishek V, Khanum F (2016) Phosphatidylcholine, an edible carrier for nanoencapsulation of unstable thiamine. Food Chem 197:562–570PubMedCrossRefGoogle Scholar
  57. 57.
    Frenzel M, Krolak E, Wagner A, Steffen-Heins A (2015) Physicochemical properties of WPI coated liposomes serving as stable transporters in a real food matrix. LWT Food Sci Technol 63:527–534CrossRefGoogle Scholar
  58. 58.
    Gaber DM, Nafee N, Abdallah OY (2017) Myricetin solid lipid nanoparticles: stability assurance from system preparation to site of action European. J Pharm Sci 109:569–580Google Scholar
  59. 59.
    Gandhi A, Dutta A, Pal A, Bakshi P (2012) Recent trends of phytosomes for delivering herbal extract with improved bioavailability. J Pharmacog Phytochem 1:6–14Google Scholar
  60. 60.
    Ganesan P, Narayanasamy D (2017) Lipid nanoparticles: different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery. Sustain Chem Pharmacy 6:37–56CrossRefGoogle Scholar
  61. 61.
    García-Márquez E, Higuera-Ciapara I, Espinosa-Andrews H (2017) Design of fish oil-in-water nanoemulsion by microfluidization. Innovative Food Sci Emerg Technol 40:87–91CrossRefGoogle Scholar
  62. 62.
    Genç L, Kutlu HM, Güney G (2015) Vitamin B12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy. Pharm Dev Technol 20:337–344PubMedCrossRefGoogle Scholar
  63. 63.
    Geszke-Moritz M, Moritz M (2016) Solid lipid nanoparticles as attractive drug vehicles: composition, properties and therapeutic strategies. Mater Sci Eng C 68:982–994CrossRefGoogle Scholar
  64. 64.
    Ghanbarzadeh B, Babazadeh A, Hamishehkar H (2016) Nano-phytosome as a potential food-grade delivery system. Food Biosci 15:126–135CrossRefGoogle Scholar
  65. 65.
    Ghorbanzade T, Jafari SM, Akhavan S, Hadavi R (2017) Nano-encapsulation of fish oil in nano-liposomes and its application in fortification of yogurt. Food Chem 216:146–152PubMedCrossRefGoogle Scholar
  66. 66.
    Gleeson JP, Ryan SM, Brayden DJ (2016) Oral delivery strategies for nutraceuticals: delivery vehicles and absorption enhancers. Trends Food Sci Technol 53:90–101CrossRefGoogle Scholar
  67. 67.
    Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O (2012) Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomedicine 7:1841PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Gómez-Hens A, Fernández-Romero JM (2005) The role of liposomes in analytical processes. TrAC Trends Anal Chem 24:9–19CrossRefGoogle Scholar
  69. 69.
    Gulotta A, Saberi AH, Nicoli MC, McClements DJ (2014) Nanoemulsion-based delivery systems for polyunsaturated (ω-3) oils: formation using a spontaneous emulsification method. J Agric Food Chem 62:1720–1725PubMedCrossRefGoogle Scholar
  70. 70.
    Gutiérrez FJ et al (2013) Methods for the nanoencapsulation of β-carotene in the food sector. Trends Food Sci Technol 32:73–83CrossRefGoogle Scholar
  71. 71.
    Guttoff M, Saberi AH, McClements DJ (2015) Formation of vitamin D nanoemulsion-based delivery systems by spontaneous emulsification: factors affecting particle size and stability. Food Chem 171:117–122PubMedCrossRefGoogle Scholar
  72. 72.
    Hadian Z, Sahari MA, Moghimi HR, Barzegar M (2014) Formulation, characterization and optimization of liposomes containing eicosapentaenoic and docosahexaenoic acids; a methodology approach. IJPR 13:393PubMedGoogle Scholar
  73. 73.
    Hassanzadeh P, Arbabi E, Atyabi F, Dinarvand R (2018) Ferulic acid-loaded nanostructured lipid carriers: a promising nanoformulation against the ischemic neural injuries. Life Sci 193:64–76PubMedCrossRefGoogle Scholar
  74. 74.
    Hategekimana J, Chamba MV, Shoemaker CF, Majeed H, Zhong F (2015) Vitamin E nanoemulsions by emulsion phase inversion: effect of environmental stress and long-term storage on stability and degradation in different carrier oil types. Colloids Surf A Physicochem Eng Asp 483:70–80CrossRefGoogle Scholar
  75. 75.
    Huang J, Wang Q, Li T, Xia N, Xia Q (2017) Nanostructured lipid carrier (NLC) as a strategy for encapsulation of quercetin and linseed oil: preparation and in vitro characterization studies. J Food Eng 215:1–12CrossRefGoogle Scholar
  76. 76.
    Huang Z, Li X, Zhang T, Song Y, She Z, Li J, Deng Y (2014) Progress involving new techniques for liposome preparation. Asian J Pharmaceut Sci 9:176–182CrossRefGoogle Scholar
  77. 77.
    Isailović BD, Kostić IT, Zvonar A, Đorđević VB, Gašperlin M, Nedović VA, Bugarski BM (2013) Resveratrol loaded liposomes produced by different techniques. Innovative Food Sci Emerg Technol 19:181–189CrossRefGoogle Scholar
  78. 78.
    Jafari S, McClements D (2017) Nanotechnology approaches for increasing nutrient bioavailability. In: Advances in food and nutrition research, vol 81. Elsevier, Cambridge, MA, pp 1–30Google Scholar
  79. 79.
    Jafari SM (2017) Nanoencapsulation of food bioactive ingredients: principles and applications. Academic Press, San DiegoGoogle Scholar
  80. 80.
    Jafari SM, Assadpoor E, He Y, Bhandari B (2008) Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocoll 22:1191–1202CrossRefGoogle Scholar
  81. 81.
    Jafari SM, He Y, Bhandari B (2007a) Production of sub-micron emulsions by ultrasound and microfluidization techniques. J Food Eng 82:478–488CrossRefGoogle Scholar
  82. 82.
    Jafari SM, He Y, Bhandari B (2007b) Optimization of nano-emulsions production by microfluidization. Eur Food Res Technol 225:733–741.  https://doi.org/10.1007/s00217-006-0476-9CrossRefGoogle Scholar
  83. 83.
    Jafari SM, Paximada P, Mandala I, Assadpour E, Mehrnia MA (2017) Chapter 2: encapsulation by nanoemulsions. In: Nanoencapsulation technologies for the food and nutraceutical industries. Academic Press, London, pp 36–73CrossRefGoogle Scholar
  84. 84.
    Jafari SM, McClements DJ (2018) Nanoemulsions. Academic PressGoogle Scholar
  85. 85.
    Jahadi M, Khosravi-Darani K (2017) Liposomal encapsulation enzymes: from medical applications to kinetic characteristics. Mini Rev Med Chem 17:366–370PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Jahadi M, Khosravi-Darani K, Ehsani M-R, Saboury A, Zoghi A, Egbaltab K, Mozafari M-R (2015) Effect of protease-loaded Nanoliposome produced by heating method on yield and composition of whey and curd during the production of Iranian brined cheese. Nut Food Sci Res 2:49–53Google Scholar
  87. 87.
    Jahadi M, Khosravi-Darani K, Ehsani MR, Mozafari MR, Saboury AA, Zoghi A, Mohammadi M (2016) Modelling of proteolysis in Iranian brined cheese using proteinase-loaded nanoliposome. Int J Dairy Technol 69:57–62CrossRefGoogle Scholar
  88. 88.
    Jay JM, Loessner M, Golden D (2005) Modern food microbiology, 7th edn. Springer, New YorkGoogle Scholar
  89. 89.
    Jenning V, Gysler A, Schäfer-Korting M, Gohla SH (2000) Vitamin a loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 49:211–218PubMedCrossRefGoogle Scholar
  90. 90.
    Ji H, Tang J, Li M, Ren J, Zheng N, Wu L (2016) Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin. Drug Deliv 23:459–470PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Johnson EJ (2002) The role of carotenoids in human health. Nutr Clin Care 5:56–65PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Karadag A, Yang X, Ozcelik B, Huang Q (2013) Optimization of preparation conditions for quercetin nanoemulsions using response surface methodology. J Agric Food Chem 61:2130–2139PubMedCrossRefPubMedCentralGoogle Scholar
  93. 93.
    Karami MA, Zadeh BSM, Koochak M, Moghimipur E (2016) Superoxide dismutase-loaded solid lipid nanoparticles prepared by cold homogenization method: characterization and permeation study through burned rat skin. Jundishapur J Nat Pharmaceutical Product 11:e33968 ( https://doi.org/10.17795/jjnpp-33968)
  94. 94.
    Kareparamban JA, Nikam PH, Jadhav AP, Kadam VJ (2012) Phytosome: a novel revolution in herbal drugs. IJRPC 2:299–310Google Scholar
  95. 95.
    Karimi N, Ghanbarzadeh B, Hamishehkar H, Keivani F, Pezeshki A, Gholian MM (2015) Phytosome and liposome: the beneficial encapsulation systems in drug delivery and food application. Applied Food Biotechnol 2:17–27Google Scholar
  96. 96.
    Karthik P, Anandharamakrishnan C (2016) Enhancing omega-3 fatty acids nanoemulsion stability and in-vitro digestibility through emulsifiers. J Food Eng 187:92–105CrossRefGoogle Scholar
  97. 97.
    Katouzian I, Esfanjani AF, Jafari SM, Akhavan S (2017) Formulation and application of a new generation of lipid nano-carriers for the food bioactive ingredients. Trends Food Sci Technol 68:14–25CrossRefGoogle Scholar
  98. 98.
    Katouzian I, Jafari SM (2016) Nano-encapsulation as a promising approach for targeted delivery and controlled release of vitamins. Trends Food Sci Technol 53:34–48CrossRefGoogle Scholar
  99. 99.
    Katouzian I, Jafari SM (2017) Chapter 4: Nanoencapsulation of vitamins. In: Nanoencapsulation of food bioactive ingredients. Academic Press, London, pp 145–181CrossRefGoogle Scholar
  100. 100.
    Keivani Nahr F, Ghanbarzadeh B, Hamishehkar H, Kafil HS (2018) Food grade nanostructured lipid carrier for cardamom essential oil: preparation, characterization and antimicrobial activity. J Funct Foods 40:1–8CrossRefGoogle Scholar
  101. 101.
    Khan J, Alexander A, Saraf S, Saraf S (2013) Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J Control Release 168:50–60PubMedCrossRefPubMedCentralGoogle Scholar
  102. 102.
    Ko S, Lee S-C (2010) Effect of nanoliposomes on the stabilization of incorporated retinol. Afr J Biotechnol 9:6158–6161Google Scholar
  103. 103.
    Komaiko J, Sastrosubroto A, McClements DJ (2016) Encapsulation of ω-3 fatty acids in nanoemulsion-based delivery systems fabricated from natural emulsifiers: sunflower phospholipids. Food Chem 203:331–339PubMedCrossRefPubMedCentralGoogle Scholar
  104. 104.
    Lacatusu I, Badea N, Stan R, Meghea A (2012) Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol. Nanotechnology 23:455702PubMedCrossRefPubMedCentralGoogle Scholar
  105. 105.
    Lane KE, Li W, Smith CJ, Derbyshire EJ (2016) The development of vegetarian omega-3 oil in water nanoemulsions suitable for integration into functional food products. J Funct Foods 23:306–314CrossRefGoogle Scholar
  106. 106.
    Lee H, Yildiz G, Dos Santos L, Jiang S, Andrade J, Engeseth N, Feng H (2016) Soy protein nano-aggregates with improved functional properties prepared by sequential pH treatment and ultrasonication. Food Hydrocoll 55:200–209CrossRefGoogle Scholar
  107. 107.
    Li H, Zhao X, Ma Y, Zhai G, Li L, Lou H (2009) Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release 133:238–244PubMedCrossRefPubMedCentralGoogle Scholar
  108. 108.
    Li M, Zahi MR, Yuan Q, Tian F, Liang H (2016) Preparation and stability of astaxanthin solid lipid nanoparticles based on stearic acid. Eur J Lipid Sci Technol 118:592–602CrossRefGoogle Scholar
  109. 109.
    Li T et al (2015) Preparation and characterization of nanoscale complex liposomes containing medium-chain fatty acids and vitamin C. Int J Food Prop 18:113–124CrossRefGoogle Scholar
  110. 110.
    Lin C-H, Chen C-H, Lin Z-C, Fang J-Y (2017) Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. J Food Drug Anal 25:219–234PubMedCrossRefGoogle Scholar
  111. 111.
    Lin Q, Liang R, Williams PA, Zhong F (2018) Factors affecting the bioaccessibility of β-carotene in lipid-based microcapsules: digestive conditions, the composition, structure and physical state of microcapsules. Food Hydrocoll 77:187–203Google Scholar
  112. 112.
    Liu L et al (2014) Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers colloids and surfaces B. Biointerfaces 115:125–131PubMedCrossRefGoogle Scholar
  113. 113.
    Liu W, Tian M, Kong Y, Lu J, Li N, Han J (2017) Multilayered vitamin C nanoliposomes by self-assembly of alginate and chitosan: long-term stability and feasibility application in mandarin juice. LWT Food Sci Technol 75:608–615CrossRefGoogle Scholar
  114. 114.
    Livney YD (2015) Nanostructured delivery systems in food: latest developments and potential future directions. Curr Opin Food Sci 3:125–135CrossRefGoogle Scholar
  115. 115.
    López-Rubio A, Lagaron JM (2012) Whey protein capsules obtained through electrospraying for the encapsulation of bioactives. Innovative Food Sci Emerg Technol 13:200–206CrossRefGoogle Scholar
  116. 116.
    Lu W-C, Huang D-W, Wang C-C, Yeh C-H, Tsai J-C, Huang Y-T, Li P-H (2018) Preparation, characterization, and antimicrobial activity of nanoemulsions incorporating citral essential oil. J Food Drug Anal 26(1):82–89Google Scholar
  117. 117.
    Lu W, Kelly AL, Miao S (2016) Emulsion-based encapsulation and delivery systems for polyphenols. Trends Food Sci Technol 47:1–9CrossRefGoogle Scholar
  118. 118.
    Madrigal-Carballo S, Lim S, Rodriguez G, Vila AO, Krueger CG, Gunasekaran S, Reed JD (2010) Biopolymer coating of soybean lecithin liposomes via layer-by-layer self-assembly as novel delivery system for ellagic acid. J Funct Foods 2:99–106CrossRefGoogle Scholar
  119. 119.
    Mahdavi SA, Jafari SM, Ghorbani M, Assadpoor E (2014) Spray-drying microencapsulation of anthocyanins by natural biopolymers: a review. Dry Technol 32:509–518CrossRefGoogle Scholar
  120. 120.
    Mahdavee Khazaei K, Jafari SM, Ghorbani M, Hemmati Kakhki A (2014) Application of maltodextrin and gum Arabic in microencapsulation of saffron petal's anthocyanins and evaluating their storage stability and color. Carbohydr Polym 105:57–62PubMedCrossRefGoogle Scholar
  121. 121.
    Maherani B, Arab-Tehrany E, Mozafari MR, Gaiani C, Linder M (2011) Liposomes: a review of manufacturing techniques and targeting strategies. Curr Nanosci 7:436–452CrossRefGoogle Scholar
  122. 122.
    Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ (2007) Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60:171–177PubMedCrossRefGoogle Scholar
  123. 123.
    Marsanasco M, Márquez AL, Wagner JR, Alonso SV, Chiaramoni NS (2011) Liposomes as vehicles for vitamins E and C: an alternative to fortify orange juice and offer vitamin C protection after heat treatment. Food Res Int 44:3039–3046CrossRefGoogle Scholar
  124. 124.
    Martins N, Roriz CL, Morales P, Barros L, Ferreira IC (2016) Food colorants: challenges, opportunities and current desires of agro-industries to ensure consumer expectations and regulatory practices. Trends Food Sci Technol 52:1–15CrossRefGoogle Scholar
  125. 125.
    Maruyama K et al (2004) Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT). J Control Release 98:195–207PubMedCrossRefGoogle Scholar
  126. 126.
    Maté J, Periago PM, Palop A (2016) Combined effect of a nanoemulsion of D-limonene and nisin on Listeria monocytogenes growth and viability in culture media and foods. Food Sci Technol Int 22:146–152PubMedCrossRefGoogle Scholar
  127. 127.
    McClements DJ (2012) Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8:1719–1729CrossRefGoogle Scholar
  128. 128.
    McClements DJ, Rao J (2011) Food-grade Nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr 51:285–330.  https://doi.org/10.1080/10408398.2011.559558CrossRefPubMedGoogle Scholar
  129. 129.
    Mehmood T (2015) Optimization of the canola oil based vitamin E nanoemulsions stabilized by food grade mixed surfactants using response surface methodology. Food Chem 183:1–7PubMedCrossRefGoogle Scholar
  130. 130.
    Mehrad B, Ravanfar R, Licker J, Regenstein JM, Abbaspourrad A (2018) Enhancing the physicochemical stability of β-carotene solid lipid nanoparticle (SLNP) using whey protein isolate. Food Res Int 105:962–969PubMedCrossRefGoogle Scholar
  131. 131.
    Mehrnia MA, Jafari SM, Makhmal-Zadeh BS, Maghsoudlou Y (2016) Crocin loaded nano-emulsions: factors affecting emulsion properties in spontaneous emulsification. Int J Biol Macromol 84:261–267PubMedCrossRefPubMedCentralGoogle Scholar
  132. 132.
    Mehrnia M-A, Jafari S-M, Makhmal-Zadeh BS, Maghsoudlou Y (2017) Rheological and release properties of double nano-emulsions containing crocin prepared with Angum gum, Arabic gum and whey protein. Food Hydrocoll 66:259–267CrossRefGoogle Scholar
  133. 133.
    Mendes J et al (2018) Chemical composition and antibacterial activity of Eugenia brejoensis essential oil nanoemulsions against Pseudomonas fluorescens. LWT 93:659–664CrossRefGoogle Scholar
  134. 134.
    Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A (2017) Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 85:102–112PubMedCrossRefPubMedCentralGoogle Scholar
  135. 135.
    Mohammadi M, Pezeshki A, Abbasi MM, Ghanbarzadeh B, Hamishehkar H (2017) Vitamin D3-loaded nanostructured lipid carriers as a potential approach for fortifying food beverages; in vitro and in vivo evaluation. Adv Pharmaceutical Bulletin 7:61CrossRefGoogle Scholar
  136. 136.
    Mohammadi R, Mahmoudzade M, Atefi M, Khosravi-Darani K, Mozafari M (2015) Applications of nanoliposomes in cheese technology. Int J Dairy Technol 68:11–23CrossRefGoogle Scholar
  137. 137.
    Mohammadi A, Jafari SM, Esfanjani AF, Akhavan S (2016a) Application of nano-encapsulated olive leaf extract in controlling the oxidative stability of soybean oil. Food Chem 190:513–519PubMedCrossRefPubMedCentralGoogle Scholar
  138. 138.
    Mohammadi A, Jafari SM, Assadpour E, Faridi Esfanjani A (2016b) Nano-encapsulation of olive leaf phenolic compounds through WPC-pectin complexes and evaluating their release rate. Int J Biol Macromol 82:816–822PubMedCrossRefPubMedCentralGoogle Scholar
  139. 139.
    Mokhtari S, Jafari SM, Assadpour E (2017) Development of a nutraceutical nano-delivery system through emulsification/internal gelation of alginate. Food Chem 229:286–295PubMedCrossRefPubMedCentralGoogle Scholar
  140. 140.
    Morais JM, Burgess DJ (2014) In vitro release testing methods for vitamin E nanoemulsions. Int J Pharm 475:393–400PubMedCrossRefPubMedCentralGoogle Scholar
  141. 141.
    Mozafari RM (2005) Nanoliposomes: from fundamentals to recent developments. TraffordGoogle Scholar
  142. 142.
    Mukherjee K, Maiti K, Venkatesh M, Mukherjee P (2008) Phytosome of hesperetin, a value added formulation with phytomolecules. In: 60th Indian Pharmaceutical CongressGoogle Scholar
  143. 143.
    Müller R, Radtke M, Wissing S (2002a) Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 242:121–128PubMedCrossRefGoogle Scholar
  144. 144.
    Müller RH, Radtke M, Wissing SA (2002b) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 54:S131–S155PubMedCrossRefPubMedCentralGoogle Scholar
  145. 145.
    Munin A, Edwards-Lévy F (2011) Encapsulation of natural polyphenolic compounds: a review. Pharmaceutics 3:793–829PubMedPubMedCentralCrossRefGoogle Scholar
  146. 146.
    Nejadmansouri M, Hosseini SMH, Niakosari M, Yousefi GH, Golmakani MT (2016) Physicochemical properties and storage stability of ultrasound-mediated WPI-stabilized fish oil nanoemulsions. Food Hydrocoll 61:801–811CrossRefGoogle Scholar
  147. 147.
    Ni S, Hu C, Sun R, Zhao G, Xia Q (2017) Nanoemulsions-based delivery Systems for Encapsulation of quercetin: preparation, characterization, and cytotoxicity studies. J Food Process Eng 40:e12374 ( https://doi.org/10.1111/jfpe.12374)
  148. 148.
    Nunes S, Madureira AR, Campos D, Sarmento B, Gomes AM, Pintado M, Reis F (2017) Solid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applications. Crit Rev Food Sci Nutr 57:1863–1873PubMedPubMedCentralGoogle Scholar
  149. 149.
    Ojagh SM, Hasani S (2018) Characteristics and oxidative stability of fish oil nano-liposomes and its application in functional bread. J Food Measur Characterization 12(2):1084–1092Google Scholar
  150. 150.
    Oliveira DRB, Michelon M, de Figueiredo FG, Sinigaglia-Coimbra R, Cunha RL (2016) β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method. Food Res Int 90:139–146PubMedCrossRefPubMedCentralGoogle Scholar
  151. 151.
    Öztürk B (2017) Nanoemulsions for food fortification with lipophilic vitamins: production challenges, stability, and bioavailability. Eur J Lipid Sci Technol 119:1500539 ( https://doi.org/10.1002/ejlt.201500539)
  152. 152.
    Ozturk B, Argin S, Ozilgen M, McClements DJ (2014) Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural surfactants: Quillaja saponin and lecithin. J Food Eng 142:57–63CrossRefGoogle Scholar
  153. 153.
    Pandita D, Kumar S, Poonia N, Lather V (2014) Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Res Int 62:1165–1174CrossRefGoogle Scholar
  154. 154.
    Panpipat W, Dong M, Xu X, Guo Z (2013) Thermal properties and nanodispersion behavior of synthesized β-sitosteryl acyl esters: a structure–activity relationship study. J Colloid Interface Sci 407:177–186PubMedCrossRefPubMedCentralGoogle Scholar
  155. 155.
    Park SJ, Garcia CV, Shin GH, Kim JT (2017) Development of nanostructured lipid carriers for the encapsulation and controlled release of vitamin D3. Food Chem 225:213–219PubMedCrossRefPubMedCentralGoogle Scholar
  156. 156.
    Park SJ, Garcia CV, Shin GH, Kim JT (2018) Improvement of curcuminoid bioaccessbility from turmeric by a nanostructured lipid carrier system. Food Chem 251(15):51–57Google Scholar
  157. 157.
    Patel AR, Bhandari B (2014) Nano-and microencapsulation of vitamins. In: Nano-and microencapsulation for foods. Wiley, Chichester, pp 223–248CrossRefGoogle Scholar
  158. 158.
    Patel MR, Martin-Gonzalez S, Fernanda M (2012) Characterization of ergocalciferol loaded solid lipid nanoparticles. J Food Sci 77(1):N8–13Google Scholar
  159. 159.
    Pezeshki A, Ghanbarzadeh B, Mohammadi M, Fathollahi I, Hamishehkar H (2014) Encapsulation of vitamin a palmitate in nanostructured lipid carrier (NLC)-effect of surfactant concentration on the formulation properties. Adv Pharmaceutical Bulletin 4:563Google Scholar
  160. 160.
    Pezeshky A, Ghanbarzadeh B, Hamishehkar H, Moghadam M, Babazadeh A (2016) Vitamin A palmitate-bearing nanoliposomes: preparation and characterization. Food Biosci 13:49–55CrossRefGoogle Scholar
  161. 161.
    Pinheiro AC, Coimbra MA, Vicente AA (2016) In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers–effect of interfacial composition. Food Hydrocoll 52:460–467CrossRefGoogle Scholar
  162. 162.
    Pinilla CMB, Brandelli A (2016) Antimicrobial activity of nanoliposomes co-encapsulating nisin and garlic extract against gram-positive and gram-negative bacteria in milk. Innovative Food Sci Emerg Technol 36:287–293CrossRefGoogle Scholar
  163. 163.
    Pinto F, de Barros DP, Fonseca LP (2018) Design of multifunctional nanostructured lipid carriers enriched with α-tocopherol using vegetable oils. Ind Crop Prod 118:149–159CrossRefGoogle Scholar
  164. 164.
    Porter CJ, Trevaskis NL, Charman WN (2007) Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 6:231PubMedCrossRefPubMedCentralGoogle Scholar
  165. 165.
    Pourashouri P, Shabanpour B, Razavi SH, Jafari SM, Shabani A, Aubourg SP (2014) Impact of wall materials on physicochemical properties of microencapsulated fish oil by spray drying. Food Bioprocess Technol 7:2354–2365CrossRefGoogle Scholar
  166. 166.
    Prombutara P, Kulwatthanasal Y, Supaka N, Sramala I, Chareonpornwattana S (2012) Production of nisin-loaded solid lipid nanoparticles for sustained antimicrobial activity. Food Control 24:184–190CrossRefGoogle Scholar
  167. 167.
    Pyo S-M, Müller RH, Keck CM (2017) Encapsulation by nanostructured lipid carriers. In: Nanoencapsulation technologies for the food and nutraceutical industries. Elsevier, London, pp 114–137CrossRefGoogle Scholar
  168. 168.
    Qi C, Chen Y, Huang JH, Jin QZ, Wang XG (2012) Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine. J Sci Food Agric 92:787–793PubMedCrossRefPubMedCentralGoogle Scholar
  169. 169.
    Rabelo CA, Taarji N, Khalid N, Kobayashi I, Nakajima M, Neves MA (2018) Formulation and characterization of water-in-oil nanoemulsions loaded with açaí berry anthocyanins: insights of degradation kinetics and stability evaluation of anthocyanins and nanoemulsions. Food Res Int 106:542–548Google Scholar
  170. 170.
    Radhakrishnan R, Kulhari H, Pooja D, Gudem S, Bhargava S, Shukla R, Sistla R (2016) Encapsulation of biophenolic phytochemical EGCG within lipid nanoparticles enhances its stability and cytotoxicity against cancer. Chem Phys Lipids 198:51–60PubMedCrossRefPubMedCentralGoogle Scholar
  171. 171.
    Rafiee Z, Barzegar M, Sahari MA, Maherani B (2017) Nanoliposomal carriers for improvement the bioavailability of high–valued phenolic compounds of pistachio green hull extract. Food Chem 220:115–122PubMedCrossRefPubMedCentralGoogle Scholar
  172. 172.
    Rao J, McClements DJ (2011) Food-grade microemulsions, nanoemulsions and emulsions: fabrication from sucrose monopalmitate & lemon oil. Food Hydrocoll 25:1413–1423CrossRefGoogle Scholar
  173. 173.
    Rashidinejad A, Birch EJ, Sun-Waterhouse D, Everett DW (2014) Delivery of green tea catechin and epigallocatechin gallate in liposomes incorporated into low-fat hard cheese. Food Chem 156:176–183PubMedCrossRefPubMedCentralGoogle Scholar
  174. 174.
    Rashidinejad A, Birch EJ, Sun-Waterhouse D, Everett DW (2016) Effect of liposomal encapsulation on the recovery and antioxidant properties of green tea catechins incorporated into a hard low-fat cheese following in vitro simulated gastrointestinal digestion. Food Bioprod Process 100:238–245CrossRefGoogle Scholar
  175. 175.
    Rasti B, Erfanian A, Selamat J (2017) Novel nanoliposomal encapsulated omega-3 fatty acids and their applications in food. Food Chem 230:690–696PubMedCrossRefPubMedCentralGoogle Scholar
  176. 176.
    Ravanfar R, Tamaddon AM, Niakousari M, Moein MR (2016) Preservation of anthocyanins in solid lipid nanoparticles: optimization of a microemulsion dilution method using the placket–Burman and box–Behnken designs. Food Chem 199:573–580PubMedCrossRefPubMedCentralGoogle Scholar
  177. 177.
    Ribeiro H, Gupta R, Smith K, van Malssen K, Popp A, Velikov K (2016) Super-cooled and amorphous lipid-based colloidal dispersions for the delivery of phytosterols. Soft Matter 12:5835–5846PubMedCrossRefPubMedCentralGoogle Scholar
  178. 178.
    Righeschi C, Bergonzi MC, Isacchi B, Bazzicalupi C, Gratteri P, Bilia AR (2016) Enhanced curcumin permeability by SLN formulation: the PAMPA approach. LWT Food Sci Technol 66:475–483CrossRefGoogle Scholar
  179. 179.
    Saberi AH, Fang Y, McClements DJ (2013) Fabrication of vitamin E-enriched nanoemulsions by spontaneous emulsification: effect of propylene glycol and ethanol on formation, stability, and properties. Food Res Int 54:812–820CrossRefGoogle Scholar
  180. 180.
    Salminen H, Aulbach S, Leuenberger BH, Tedeschi C, Weiss J (2014) Influence of surfactant composition on physical and oxidative stability of Quillaja saponin-stabilized lipid particles with encapsulated ω-3 fish oil. Colloids Surf B: Biointerfaces 122:46–55PubMedCrossRefPubMedCentralGoogle Scholar
  181. 181.
    Salminen H, Gömmel C, Leuenberger BH, Weiss J (2016) Influence of encapsulated functional lipids on crystal structure and chemical stability in solid lipid nanoparticles: towards bioactive-based design of delivery systems. Food Chem 190:928–937PubMedCrossRefPubMedCentralGoogle Scholar
  182. 182.
    Salvia-Trujillo L, Soliva-Fortuny R, Rojas-Graü MA, McClements DJ, Martín-Belloso O (2017) Edible nanoemulsions as carriers of active ingredients: a review. Annu Rev Food Sci Technol 8:439–466PubMedCrossRefPubMedCentralGoogle Scholar
  183. 183.
    Santana R, Perrechil F, Cunha R (2013) High-and low-energy emulsifications for food applications: a focus on process parameters. Food Eng Rev 5:107–122CrossRefGoogle Scholar
  184. 184.
    Saraf S (2010) Applications of novel drug delivery system for herbal formulations. Fitoterapia 81:680–689PubMedCrossRefPubMedCentralGoogle Scholar
  185. 185.
    Sari TP, Mann B, Kumar R, Singh RRB, Sharma R, Bhardwaj M, Athira S (2015) Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocoll 43:540–546CrossRefGoogle Scholar
  186. 186.
    Saxena V, Hasan A, Sharma S, Pandey LM (2018) Edible oil nanoemulsion: an organic nanoantibiotic as a potential biomolecule delivery vehicle. Int J Polym Mater Polym Biomater 67:410–419CrossRefGoogle Scholar
  187. 187.
    Sebaaly C, Jraij A, Fessi H, Charcosset C, Greige-Gerges H (2015) Preparation and characterization of clove essential oil-loaded liposomes. Food Chem 178:52–62PubMedCrossRefPubMedCentralGoogle Scholar
  188. 188.
    Semalty A, Semalty M, Rawat MSM, Franceschi F (2010) Supramolecular phospholipids–polyphenolics interactions: the PHYTOSOME® strategy to improve the bioavailability of phytochemicals. Fitoterapia 81:306–314PubMedCrossRefPubMedCentralGoogle Scholar
  189. 189.
    Sessa M et al (2014) Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Food Chem 147:42–50PubMedCrossRefPubMedCentralGoogle Scholar
  190. 190.
    Shah R, Eldridge D, Palombo E, Harding I (2015) Lipid nanoparticles: production, characterization and stability. Springer, BerlinGoogle Scholar
  191. 191.
    Shin GH, Chung SK, Kim JT, Joung HJ, Park HJ (2013) Preparation of chitosan-coated nanoliposomes for improving the mucoadhesive property of curcumin using the ethanol injection method. J Agric Food Chem 61:11119–11126PubMedCrossRefPubMedCentralGoogle Scholar
  192. 192.
    Shin GH, Kim JT, Park HJ (2015) Recent developments in nanoformulations of lipophilic functional foods. Trends Food Sci Technol 46:144–157CrossRefGoogle Scholar
  193. 193.
    Sindhumol P, Thomas M, Mohanachandran P (2010) Phytosomes: a novel dosage form for enhancement of bioavailability of botanicals and neutraceuticals. Int J Pharm Pharm Sci 2:10–14Google Scholar
  194. 194.
    Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma M (2005) Nano-emulsions. Curr Opin Colloid Interface Sci 10:102–110CrossRefGoogle Scholar
  195. 195.
    Soleimanian Y, Goli SAH, Varshosaz J, Sahafi SM (2018) Formulation and characterization of novel nanostructured lipid carriers made from beeswax, propolis wax and pomegranate seed oil. Food Chem 244:83–92PubMedCrossRefPubMedCentralGoogle Scholar
  196. 196.
    Soukoulis C, Bohn T (2018) A comprehensive overview on the micro-and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids. Crit Rev Food Sci Nutr 58:1–36PubMedCrossRefPubMedCentralGoogle Scholar
  197. 197.
    Sun J, Bi C, Chan HM, Sun S, Zhang Q, Zheng Y (2013) Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids Surf B: Biointerfaces 111:367–375PubMedCrossRefGoogle Scholar
  198. 198.
    Takahashi M, Uechi S, Takara K, Asikin Y, Wada K (2009) Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem 57:9141–9146PubMedCrossRefGoogle Scholar
  199. 199.
    Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A (2013) Nanostructured lipid carriers (NLC): a potential delivery system for bioactive food molecules. Innovative Food Sci Emerg Technol 19:29–43CrossRefGoogle Scholar
  200. 200.
    Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A (2014) Design and characterization of astaxanthin-loaded nanostructured lipid carriers. Innovative Food Sci Emerg Technol 26:366–374CrossRefGoogle Scholar
  201. 201.
    Tan C, Feng B, Zhang X, Xia W, Xia S (2016) Biopolymer-coated liposomes by electrostatic adsorption of chitosan (chitosomes) as novel delivery systems for carotenoids. Food Hydrocoll 52:774–784CrossRefGoogle Scholar
  202. 202.
    Tan C, Zhang Y, Abbas S, Feng B, Zhang X, Xia S (2014) Modulation of the carotenoid bioaccessibility through liposomal encapsulation. Colloids Surf B: Biointerfaces 123:692–700PubMedCrossRefGoogle Scholar
  203. 203.
    Taylor TM, Weiss J, Davidson PM, Bruce BD (2005) Liposomal nanocapsules in food science and agriculture. Crit Rev Food Sci Nutr 45:587–605PubMedCrossRefGoogle Scholar
  204. 204.
    Tian H, Lu Z, Li D, Hu J (2018) Preparation and characterization of citral-loaded solid lipid nanoparticles. Food Chem 248:78–85PubMedCrossRefGoogle Scholar
  205. 205.
    Ting Y, Jiang Y, Ho C-T, Huang Q (2014) Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods 7:112–128CrossRefGoogle Scholar
  206. 206.
    Tripathy S, Patel DK, Barob L, Naira SK (2013) A review on phytosomes, their characterization, advancement & potential for transdermal application. J Drug Del Therapeutics 3:147–152Google Scholar
  207. 207.
    Tsai W-C, Rizvi SS (2016) Liposomal microencapsulation using the conventional methods and novel supercritical fluid processes. Trends Food Sci Technol 55:61–71CrossRefGoogle Scholar
  208. 208.
    Uraiwan K, Satirapipathkul C (2016) The entrapment of vitamin E in nanostructured lipid carriers of rambutan seed fat for cosmeceutical uses. In: Key engineering materials. Trans Tech, Pfaffikon, pp 77–80Google Scholar
  209. 209.
    Walia N, Dasgupta N, Ranjan S, Chen L, Ramalingam C (2017) Fish oil based vitamin D nanoencapsulation by ultrasonication and bioaccessibility analysis in simulated gastro-intestinal tract. Ultrason Sonochem 39:623–635PubMedCrossRefGoogle Scholar
  210. 210.
    Walker RM, Decker EA, McClements DJ (2015) Physical and oxidative stability of fish oil nanoemulsions produced by spontaneous emulsification: effect of surfactant concentration and particle size. J Food Eng 164:10–20CrossRefGoogle Scholar
  211. 211.
    Wang JL et al (2014) Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. J Food Sci 79(2):E169–177Google Scholar
  212. 212.
    Weiss J, Decker EA, McClements DJ, Kristbergsson K, Helgason T, Awad T (2008) Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophysics 3:146–154CrossRefGoogle Scholar
  213. 213.
    Wu G, Li J, Yue J, Zhang S, Yunusi K (2018) Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Mol Med Rep 17:2456–2464PubMedPubMedCentralGoogle Scholar
  214. 214.
    Yadav P, Soni G, Mahor A, Alok S, Singh PP, Verma A (2014) Solid lipid nanoparticles: an effective and promising drug delivery system-a review. Int J Pharm Sci Res 5:1152Google Scholar
  215. 215.
    Yang S, Liu W, Liu C, Liu W, Tong G, Zheng H, Zhou W (2012) Characterization and bioavailability of vitamin C nanoliposomes prepared by film evaporation-dynamic high pressure microfluidization. J Dispers Sci Technol 33:1608–1614CrossRefGoogle Scholar
  216. 216.
    Yang Y, McClements DJ (2013) Encapsulation of vitamin E in edible emulsions fabricated using a natural surfactant. Food Hydrocoll 30:712–720CrossRefGoogle Scholar
  217. 217.
    Zhang J, Tang Q, Xu X, Li N (2013) Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int J Pharm 448:168–174PubMedCrossRefPubMedCentralGoogle Scholar
  218. 218.
    Zhu J, Zhuang P, Luan L, Sun Q, Cao F (2015) Preparation and characterization of novel nanocarriers containing krill oil for food application. J Funct Foods 19:902–912CrossRefGoogle Scholar
  219. 219.
    Zhuang C-Y et al (2010) Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm 394:179–185PubMedCrossRefPubMedCentralGoogle Scholar
  220. 220.
    Zou L-q et al (2014) Improved in vitro digestion stability of (−)-epigallocatechin gallate through nanoliposome encapsulation. Food Res Int 64:492–499PubMedCrossRefPubMedCentralGoogle Scholar
  221. 221.
    Radtke M, Müller, RH (2001) Nanostructured lipid drug carriers. New Drugs 2:48–52Google Scholar
  222. 222.
    Nazemiyeh E, Eskandani M, Sheikhloie H, Nazemiyeh H (2016) Formulation and physicochemical characterization of lycopene-loaded solid lipid nanoparticles. Adv Pharm Bull 6(2):235–241Google Scholar
  223. 223.
    Esquerdo V, Dotto G, Pinto L (2015) Preparation of nanoemulsions containing unsaturated fatty acid concentrate–chitosan capsules. J Colloid Interf Sci 445:137–142Google Scholar
  224. 224.
    Zhao Y, Chang Y-X, Hu X, Liu C-Y, Quan L-H, Liao Y-H (2017) Solid lipid nanoparticles for sustained pulmonary delivery of Yuxingcao essential oil: preparation, characterization and in vivo evaluation. Int J Pharmaceut 516:364–371Google Scholar
  225. 225.
    Lewies A, Wentzel JF, Jordaan A, Bezuidenhout C, Du Plessis LH (2017) Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity. Int J Pharmaceut 526:244–253Google Scholar
  226. 226.
    Qi C, Chen Y, Huang JH, Jin QZ, Wang XG (2012) Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine. J Sci Food Agric. 92:787–793Google Scholar
  227. 227.
    Chanburee S, Tiyaboonchai W (2018) Enhanced intestinal absorption of curcumin in Caco-2 cell monolayer using mucoadhesive nanostructured lipid carriers. J Biomed Mater Res B Appl Biomater. 106(2):734–741Google Scholar

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Food Materials and Process Design EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran

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