Radiation Therapy in Lymphoplasmacytic Lymphoma (Waldenström’s Macroglobulinemia)

  • Michael Oertel
  • Oliver MickeEmail author
  • Hans Theodor Eich
Living reference work entry


Lymphoplasmacytic lymphoma is an exclusion diagnosis and is defined as a neoplasia occurring in older adults in which bone marrow (less frequently lymph nodes and spleen) is infiltrated by B lymphocytes, plasmacytoid lymphocytes, or plasma cells without the fulfillment of diagnostic criteria for any other small B-cell lymphoid neoplasm with putative plasmacytic differentiation (World Health Organization, WHO classification of tumours of haematopoietic and lymphoid tissues, revised 4th edition. International Agency for Research on Cancer, Lyon, 2017). With the presence of an additional monoclonal immunoglobulin M (IgM) gradient, the disease is called Waldenström’s macroglobulinemia (WM).

Since the first report by Jan Waldenström in 1944, after whom the disease was later named, symptomatic cytopenia, hyperviscosity, and globulin/serum protein excess have been described as disease characteristics (Waldenstrom J, Acta Med Scand 117:216–247, 1944).


Lymphoma Indolent Lymphoplasmacytic Waldenström’s macroglobulinemia Stem cell transplantation 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Michael Oertel
    • 1
  • Oliver Micke
    • 2
    Email author
  • Hans Theodor Eich
    • 1
  1. 1.Department of Radiation OncologyUniversity of MuensterMuensterGermany
  2. 2.Department of Radiotherapy and Radiation OncologyFranziskus HospitalBielefeldGermany

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