Fish as a Model for Research in Space
A new facility for rearing small fish was established in the International Space Station (ISS) in 2012 and the experiments employing medaka fish and zebrafish were performed for studies of revealing the mechanism of bone loss and muscle atrophy under microgravity. Firstly, we introduce all experiments withsmall fish performed in the ISS, and then mainly report recent experiments for medaka fish. Space flight with low gravity shows decrease in bone mineral density. To identify the mechanism of this low density, unique experiments on medaka fish were performed twice at the ISS. One was a long-term experiment for the analysis of bone growth, which revealed a decrease in the mineral density. Another was a short-term experiment for live imaging of medaka transgenic lines followed by transcriptome analyses, which revealed increased expressions of five genes.
KeywordsGravity Medaka Space Bone Osteoclast Osteoblast
This work was supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (16K15778 and 16H01635).
- David H (1963) Russians discuss space radiation in conference. In: Coughlin WJ (ed) Missiles and rockets, vol 13. Bougton, Washington, D.C., p 34Google Scholar
- Iwamatsu T (1997) The integrated book for the biology of the medaka. Daigakukyouiku, Okayama JAXA homepage. http://iss.jaxa.jp/en/kiboexp/pm/aqh/. Accessed 23 Apr 2017
- Parin VV, Pravetskiy VN, Gurovskiy NN et al (1968) Some biomedical results of the experiment performed onboard the COSMOS-110 biosatellite. Space Biol 2:7–14Google Scholar
- Simmons DJ, Ruffell JE, Winter F et al (1983) Effect of spaceflight on the non-weight-bearing bones of rat skeleton. Am J Phys 244:319–326Google Scholar