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Pharmacogenomics in Spaceflight

  • Michael A. SchmidtEmail author
  • Caleb M. Schmidt
  • Thomas J. Goodwin
Living reference work entry

Abstract

Pharmacogenomics is the study of how genes influence an individual’s response to medication. By extension, pharmacogenomics is the precise analysis of gene variants that influence the regulation of drug metabolism and the attendant development of therapeutic strategies. Whereas traditional pharmacokinetics and pharmacodynamics are applied to populations in order to understand the range of a drug’s effects, pharmacogenomics can be used to personalize drug therapy to an individual. In short, pharmacogenomics represents an emergent method available to tailor drug therapy to the individual astronaut, so that the drug countermeasure solution optimizes the chance for benefit (efficacy), while minimizing the chance for adverse events (safety). While the application of pharmacogenomics is progressing on Earth, there is presently almost no application of pharmacogenomics in space. This represents a substantial gap in our capability, but it also represents an opportunity to better enable humans to thrive in the space environment. The present review explores the fundamentals of pharmacogenomics, which includes examination of the genetic variants of the primary drug-metabolizing enzymes. It next briefly summarizes the limited evidence for how the space condition may influence these systems. The pharmacogenomic implications of the current ISS drug list are explored by example. A hypothetical design reference mission is proposed to illustrate how pharmacogenomics might be employed in the space environment. In general, we highlight how the application of intelligent clinical pharmacogenomics to astronauts can be used to guide the use of pharmaceuticals in space today, while the much-needed prospective pharmacogenomic research is conducted in parallel.

Keywords

Pharmacogenomics Pharmacometabolomics Personalized medicine Precision medicine Spaceflight Astronaut CYP450 Drug metabolism 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Michael A. Schmidt
    • 1
    • 2
    Email author
  • Caleb M. Schmidt
    • 2
  • Thomas J. Goodwin
    • 1
    • 2
  1. 1.Advanced Pattern Analysis & Countermeasures GroupBoulderUSA
  2. 2.Sovaris Aerospace, LLCBoulderUSA

Section editors and affiliations

  • Marlise Araújo dos Santos
    • 1
  1. 1.Porto AlegreBrazil

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