C1 Gas Refinery
C1 gas has been considered as a feedstock for biorefinery applications because CO, CO2, and CH4 can be easily obtained from synthetic and natural gases. C1 gas-fermenting microorganisms utilize these gases as sole carbon sources to generate cellular energy. Representatives of this class of microorganisms include cyanobacteria, acetogens, and methanotrophs, which have recently been engineered for the production of chemicals from such C1 gases. As it stands, the spectrum of target chemicals is limited to methanol, ethanol, butanol, isobutanol, isobutyraldehydes, acetone, 2,3-butanediol, lactate, butyrate, and terpenoids. In this chapter, we review the metabolic pathways for assimilation of C1 gases in cyanobacteria, acetogens, and methanotrophs. We also summarize the metabolic engineering strategies for developing host strains for the production of chemicals from C1 gases.
This work was supported by grants from the C1 Gas Refinery Project (NRF-2016M3D3A1A01913250) and the Basic Science Research Program (NRF-2016R1D1A3B04933184) from the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea.
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