Encyclopedia of Animal Cognition and Behavior

Living Edition
| Editors: Jennifer Vonk, Todd Shackelford

Creatinine

  • Karthikeyan PethusamyEmail author
  • Ankita Raj
  • Sajib Kumar Sarkar
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-47829-6_461-1

Introduction

Creatinine is a nonprotein nitrogenous compound found in the blood and excreted by glomerular filtration at a constant rate (Feher 2012).

Source

Creatinine is derived from nonenzymatic degradation of creatine phosphate which is a phosphagen for vertebrate animals. Phosphagens are high-energy phosphate compounds which supply immediate but limited energy during sudden demand for skeletal muscle and brain. Creatine phosphate is a phosphagen for vertebrate animals, whereas arginine phosphate is the phosphagen for invertebrate animals.

Adenosine triphosphate (ATP) is the energy currency of the cell required for many biochemical reactions. During the sudden demand for ATP, creatine phosphokinase enzyme catalyzes the transfer of phosphoryl group from creatine phosphate to adenosine diphosphate (ADP) to produce adenosine triphosphate (ATP). This reaction is known as Lohman’s reaction.
$$ \mathrm{Creatine}\ \mathrm{Phosphate}+\mathrm{ADP}\rightleftharpoons...
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References

  1. Feher, J. (2012). 7.4 – Tubular reabsorption and secretion. In J. Feher (Ed.), Quantitative human physiology (pp. 645–655). Boston: Academic.  https://doi.org/10.1016/B978-0-12-382163-8.00072-4.CrossRefGoogle Scholar
  2. Huidobro, E., P, J., Tagle, R., & Guzmán, A. M. (2018). Estimation of glomerular filtration rate with creatinine. Revista Medica De Chile, 146(3), 344–350.  https://doi.org/10.4067/s0034-98872018000300344.CrossRefGoogle Scholar
  3. Shoker, A., Hossain, M. A., Koru-Sengul, T., Raju, D. L., & Cockcroft, D. (2006). Performance of creatinine clearance equations on the original Cockcroft-Gault population. Clinical Nephrology, 66(2), 89–97.CrossRefGoogle Scholar
  4. Stevens, L. A., Shastri, S., & Levey, A. S. (2010). Chapter 3 – Assessment of renal function. In J. Floege, R. J. Johnson, & J. Feehally (Eds.), Comprehensive clinical nephrology (4th ed., pp. 31–38). Philadelphia: Mosby.  https://doi.org/10.1016/B978-0-323-05876-6.00003-4.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Karthikeyan Pethusamy
    • 1
    Email author
  • Ankita Raj
    • 2
  • Sajib Kumar Sarkar
    • 1
  1. 1.All India Institute of Medical SciencesNew DelhiIndia
  2. 2.Vardhman Mahavir Medical CollegeNew DelhiIndia

Section editors and affiliations

  • David Hanbury
    • 1
  1. 1.Averett UniversityDanvilleUSA