Encyclopedia of Animal Cognition and Behavior

Living Edition
| Editors: Jennifer Vonk, Todd Shackelford

Homeobox Gene

  • Neelabh Neelabh
  • Akash Gautam
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-47829-6_34-1

Definition

Homeobox genes are a group of similar genes having a common DNA sequence (a homeobox) responsible for coding a homeodomain. They play a vital role in governing the formation of bodily segmentation and cell differentiation during embryonic development.

Introduction

A homeobox is comprised of a DNA sequence, around 180 base pairs long, and resides inside the genes governing the patterns of anatomical development (morphogenesis) in various organisms like plants, fungi, and animals (Gehring 1992). These genes were initially described in Drosophila melanogaster where they function as the master regulators of the various bodily segmentation and structures during the embryonic development process (Schofield 1987). They code for a string of 60 amino acids termed as homeodomain. An important feature of the homeobox genes is that they are present on every human chromosome, often appearing in clusters (Boncinelli 1997).

The Homeodomain

Homeodomain is the part of the protein that...

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References

  1. Boncinelli, E. (1997). Homeobox genes and disease. Current Opinion in Genetics & Development, 7, 331–337.CrossRefGoogle Scholar
  2. Bürglin, T. (2001). Homeobox. In S. Brenner & J. Miller (Eds.), Encyclopedia of genetics (pp. 958–962). Academic, New York.CrossRefGoogle Scholar
  3. Bürglin, T. R., & Affolter, M. (2016). Homeodomain proteins: An update. Chromosoma, 125, 497–521.CrossRefGoogle Scholar
  4. Catron, K. M., Iler, N., & Abate, C. (1993). Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins. Molecular and Cellular Biology, 13, 2354–2365.CrossRefGoogle Scholar
  5. Gehring, W. J. (1992). The homeobox in perspective. Trends in Biochemical Sciences, 17, 277–280.CrossRefGoogle Scholar
  6. Gehring, W. J. (1993). Exploring the homeobox. Gene, 135, 215–221.CrossRefGoogle Scholar
  7. Holland, P. W., Booth, H. A. F., & Bruford, E. A. (2007). Classification and nomenclature of all human homeobox genes. BMC Biology, 5, 47.CrossRefGoogle Scholar
  8. Schofield, P. N. (1987). Patterns, puzzles and paradigms: The riddle of the homeobox. Trends in Neurosciences, 10, 3–6.CrossRefGoogle Scholar
  9. Zhao, Y., & Westphal, H. (2002). Homeobox genes and human genetic disorders. Current Molecular Medicine, 2, 13–23.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Zoology (MMV), Institute of ScienceBanaras Hindu UniversityVaranasiIndia
  2. 2.Centre for Neural and Cognitive Sciences, School of Medical SciencesUniversity of HyderabadHyderabadIndia

Section editors and affiliations

  • Akash Gautam
    • 1
  1. 1.Centre for Neural and Cognitive Sciences, School of Medical SciencesUniversity of HyderabadHyderabadIndia