Definition
Quantitative Trait Loci (QTL) are genetic segments containing one or more genes that correlate with phenotypic variation in a quantitative trait.
Introduction
Advances in DNA sequencing over the last 25 years have reduced the cost to generate a high-quality draft of the human genome from hundreds of millions to less than $1,500 (Wetterstrand 2018). The ease of access to sequence data has led to remarkable growth and demand for sequence analysis – how changes in genes and gene expression contribute to morphology and disease. For scientists, the process of connecting a phenotype to a gene can be complex. Many human traits and diseases are not solely determined by alleles at a single genetic locus that produce discrete “all-or-none” phenotypic effects, as was the case for Gregor Mendel’s pea plant seeds being smooth or wrinkled, yellow or green. Instead, many complex traits, diseases, and disease susceptibilities are influenced by interactions between alleles at multiple...
References
Consortium, T. C. (2003). Guidelines: The nature and identification of quantitative trait loci: A community’s view. Nature Reviews Genetics, 4(11), 911–916. https://doi.org/10.1038/nrg1206.
Economopoulou, P., Dimitriadis, G., & Psyrri, A. (2015). Beyond BRCA: New hereditary breast cancer susceptibility genes. Cancer Treatment Reviews, 41(1), 1–8. https://doi.org/10.1016/j.ctrv.2014.10.008.
He, M., Qi, L., Xu, M., Zhang, B., Chen, P., Lee, J., & Liang, J. (2015). Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddu583.
Jorde, L. B., Carey, J. C., & Bamshad, M. J. (2016). Medical genetics. Philadelphia: Elsevier.
Kuchenbaecker, K. B., Hopper, J. L., Barnes, D. R., Philips, K. A., Mooiji, T., Roos-Blom, M. J., & Olsson, H. (2017). Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. https://doi.org/10.1001/jama.2017.7112.
Miles, C., & Wayne, M. (2008). Quantitative Trait Locus (QTL) Analysis. Nature Education. Retrieved from https://www.nature.com/scitable/topicpage/quantitative-trait-locus-qtl-analysis-53904
Moyer, V. A. (2014). Risk Assessment, genetic counseling and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine, 160. Retrieved from https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
Remington, L., & Purugganan, D. (2003). Candidate genes, quantitative trait loci, and functional trait evolution in plants. International Journal of Plant Sciences. Retrieved from http://puruggananlab.bio.nyu.edu/pdf/remington2003.pdf
Stolk, R., Rosmalen, J., Postma, D., Boer, R., Navis, G., Slaets, J., …, & Wolffenbuttel, B. (2008). Universal risk factors for multifactorial diseases. European Journal of Epidemiology, 67–74. https://doi.org/10.1007/s10654-007-9204-4.
Wetterstrand, K. A. (2018, April 25). The Cost of Sequencing a Human Genome. Retrieved from www.genome.gov/sequencingcostsdata
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Brandenberger, L. (2018). Quantitative Trait Loci (QTL). In: Vonk, J., Shackelford, T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-47829-6_209-1
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DOI: https://doi.org/10.1007/978-3-319-47829-6_209-1
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