Obesity pp 1-32 | Cite as

Obesity and Type 2 Diabetes

Living reference work entry
Part of the Endocrinology book series (ENDOCR)


This chapter separately describes the pathophysiology of type 2 diabetes and that of obesity, and identifies the relationship between these states. The important concept of long-term reversibility of type 2 diabetes is discussed along with the beta-cell dedifferentiation, which explains the insulin secretory defect.

Obesity brings about distinct pathophysiological changes as a consequence of individuals’ pattern of food intake and levels of activity. The practical issue of clinical management is considered with particular reference to the weight management goals for type 2 diabetes.

Following therapeutic weight loss in both conditions, long-term avoidance of weight regain is vital and is optimally achieved by a combination of ongoing food energy restriction and daily physical activity.


Type 2 Diabetes Pathophysiology Twin Cycle Hypothesis De novo lipogenesis Obesity Whitehall II study Hepatic insulin resistance Long term reversibility of type 2 Diabetes Counterpoint study Counterbalance study Beta-Cell Dedifferentiation Beta-Cell reduction Impairment of insulin secretion Beta-Cell exhaustion Desensitization of Beta-Cell Endoplasmic reticulum (ER) stress Deposition of amyloid Muscle insulin resistance Liver insulin resistance Intracellular insulin action Elevation of non-esterified-fatty-acids (NEFA) Insulin resistance and mitochondrial function IRS-2 phosphorylation Physical inactivity Visceral fat Ectopic fat Subcutaneous adipose tissue Personal fat threshold (PFT) hypothesis Management of body weight Diabetes in Remission Clinical Trial (DiRECT) Type 2 Diabetes dietary management Dietary management for weight loss United Kingdom Prospective Diabetes Study (UKPDS) The Look AHEAD study (Action for Health in Diabetes Study) Avoidance of weight regain approaches Exercise Bariatric Surgery 


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Authors and Affiliations

  1. 1.Newcastle Magnetic Resonance CentreCampus for Ageing and Vitality, Newcastle UniversityNewcastle upon TyneUK

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