Extrusion-Based Biofabrication in Tissue Engineering and Regenerative Medicine

  • Monika HospodiukEmail author
  • Kazim Kerim Moncal
  • Madhuri Dey
  • Ibrahim T. Ozbolat
Reference work entry
Part of the Reference Series in Biomedical Engineering book series (RSBE)


Extrusion-based bioprinting is a powerful three-dimensional (3D) bioprinting technology that provides unique opportunities for use in organ fabrication. This technology has grown rapidly during the last decade. Extrusion-based bioprinting provides great versatility in printing various biological compounds or devices, including cells, tissues, organoids, and microfluidic devices that can be applied in basic research, pharmaceutics, drug testing, transplantation, and clinical uses. Extrusion-based bioprinting offers great flexibility in printing wide range of bioinks, including tissue spheroids, cell pellets, microcarriers, decellularized matrix components, and cell-laden hydrogels. Despite these assets, extrusion-based bioprinting has several limitations, such as inadequate control and resolution cell deposition, to create a complex tissue micro-microenvironment, shear stress-induced cell damage, and constraints associated with the current bioink materials.



This work has been supported by National Science Foundation CMMI Awards 1349716 and 1462232. We thank Fisayo Olashore and Donna Sosnoski from the Pennsylvania State University for improving the quality of the paper. The authors are grateful to the support from the Engineering Science and Mechanics Department and the College of Engineering at the Penn State University. The authors confirm that there are no known conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Monika Hospodiuk
    • 1
    • 2
    Email author
  • Kazim Kerim Moncal
    • 1
    • 2
  • Madhuri Dey
    • 1
    • 3
  • Ibrahim T. Ozbolat
    • 1
    • 2
    • 4
    • 5
  1. 1.The Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkUSA
  2. 2.Engineering Science and Mechanics DepartmentThe Pennsylvania State UniversityUniversity ParkUSA
  3. 3.Department of ChemistryThe Pennsylvania State UniversityUniversity ParkUSA
  4. 4.Biomedical Engineering DepartmentThe Pennsylvania State UniversityUniversity ParkUSA
  5. 5.Materials Research InstituteThe Pennsylvania State UniversityUniversity ParkUSA

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