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Hematopoiesis and Aging

  • Nancy K. Gillis
  • Lynn C. Moscinski
  • Eric Padron
Living reference work entry

Abstract

It is apparent that hematopoiesis, the formation and differentiation of the cellular components of blood, and bone marrow function are altered with aging, but the physiologic basis has yet to be fully elucidated. Specifically, the aging process is typically characterized by a reduction in functional reserve capacity. Thus, while basal function is normal, the ability to respond to increasing demand and infectious or inflammatory stress is compromised. In this chapter we provide a brief overview of normal, healthy bone marrow regulation and function and discuss changes observed with aging. These changes affect both intrinsic (e.g., pluripotent stem cells and committed hematopoietic precursors) and extrinsic (e.g., stroma and cytokines) factors of bone marrow function. The idiopathic acquisition of somatic mutations that occurs in elderly individuals, termed clonal hematopoiesis of indeterminate potential, is also discussed. We conclude with a discussion of the functional changes in immune function, mediated by bone marrow B and T cells, that are observed in aging individuals.

Keywords

Hematopoiesis Bone marrow Aging Clonal hematopoiesis Stem cells Cytokines CFU-S CHIP 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Nancy K. Gillis
    • 1
  • Lynn C. Moscinski
    • 2
  • Eric Padron
    • 3
  1. 1.Department of Cancer EpidemiologyMoffitt Cancer CenterTampaUSA
  2. 2.Department of HematopathologyMoffitt Cancer CenterTampaUSA
  3. 3.Department of Malignant HematologyMoffitt Cancer CenterTampaUSA

Section editors and affiliations

  • William Dale
    • 1
  1. 1.Department of Supportive Care MedicineCity of Hope Duarte - Comprehensive Cancer CenterDuarteUSA

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