Kidney Cancer in Older Adults

  • Ravindran KanesvaranEmail author
  • Hui Shan Tan
Living reference work entry


RCC is a relatively common cancer that predominantly afflicts the elderly. About one third of all RCC patients are metastatic at diagnosis, while recurrence rates of those treated for localized disease are as high as 50%. There are a number of issues unique to the older adult with RCC which needs to be taken into account before assigning the appropriate treatment to them. Although new drugs approved for mRCC were assessed without age limitation and included patients over 65 years, no prospective trials dedicated to older RCC patients are available. All the phase III mRCC trials conducted thus far showed no differences in efficacy and toxicity in younger patients compared to older patients (>65 years old). A similar scenario is also observed in the setting of the treatment of localized RCC in the elderly. This textbook chapter aims to highlight the unique issues afflicting the elderly with both localized and metastatic RCC and comprehensively review the key treatment modalities that are currently used in their management.


Geriatric Older generation Kidney cancer Renal cell carcinoma Guidelines 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Medical OncologyNational Cancer Centre SingaporeSingaporeSingapore

Section editors and affiliations

  • Etienne Brain
    • 1
  1. 1.Department of Medical OncologyInstitut Curie/Hôpital René HugueninSaint-CloudFrance

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