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Systemic Treatment of Castration-Resistant Metastatic Prostate Cancer

  • Carmel Pezaro
  • Liang Qu
  • Ian D. Davis
Living reference work entry

Abstract

Current treatments for men with castration-resistant prostate cancer (CRPC) include the next-generation androgen receptor-targeting agents abiraterone acetate and enzalutamide, cytotoxic drugs docetaxel and cabazitaxel, immunotherapy sipuleucel-T, and radionuclide radium-223 dichloride. For men with bone metastases, the supportive bone-targeting agents zoledronic acid or denosumab are also commonly administered, although these do not improve survival. Newer treatments that aim to target specific genomic aberrations are in late-stage clinical testing. In this chapter, current and emerging treatments across the spectrum of CRPC will be reviewed, including relevant limitations and future directions from late-phase trials.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Eastern Health Clinical SchoolMonash UniversityMelbourneAustralia
  2. 2.Cancer ServicesEastern HealthBox HillAustralia

Section editors and affiliations

  • Thomas Steuber
    • 1
  1. 1.Martini-Klinik am UKE GmbHHamburgGermany

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