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Risk Assessment Based on Molecular and Genetic Markers in Prostate Cancer

  • Derya Tilki
  • Thenappan Chandrasekar
  • Alexander Kretschmer
  • Felix K. Chun
Living reference work entry

Abstract

The current treatment paradigm of prostate cancer has increasingly emphasized the importance of reliable biomarkers that help stratify patients and aid in decision-making. The rapid development of numerous novel biomarkers in the past decade has made this process much more challenging. In this chapter, we provide a comprehensive review of the widely used biomarkers that are supported by clinical evidence. Specifically, the focus will be on diagnostic (PHI®, 4K score, IsoPSA®, SelectMDx®, ConfirmMDx®, PCA3, TMPRSS2:ERG gene fusion) and prognostic (OncotypeDX GPS®, Prolaris®, ProMark®, Decipher®) biomarkers. In order to better understand the value of these biomarkers in clinical decision-making, there will be an emphasis on clinical context as the literature is reviewed.

Keywords

Biomarker Prostate cancer Molecular marker Genetic marker Prognostic 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Derya Tilki
    • 1
    • 2
  • Thenappan Chandrasekar
    • 3
  • Alexander Kretschmer
    • 4
    • 5
  • Felix K. Chun
    • 2
  1. 1.Martini-Klinik Prostate Cancer CenterUniversity Hospital Hamburg-EppendorfHamburgGermany
  2. 2.Department of UrologyUniversity Hospital Hamburg-EppendorfHamburgGermany
  3. 3.Department of Urology Sidney Kimmel Cancer CenterThomas Jefferson University/Thomas Jefferson University HospitalPhiladelphiaUSA
  4. 4.The Vancouver Prostate Centre and Department of Urological SciencesUniversity of British ColumbiaVancouverCanada
  5. 5.Department of UrologyLudwig-Maximilians University MunichMunichGermany

Section editors and affiliations

  • Thomas Steuber
    • 1
  1. 1.Martini-Klinik am UKE GmbHHamburgGermany

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