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Bioadhesives

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Handbook of Adhesion Technology

Abstract

Bioadhesion is a versatile tool used by many organisms for a variety of purposes. It has roles to play in construction, predation, defense, and attachment and covers different concepts based on biochemical and mechanical principles. The specific request on the bond combined with millions of years of evolution results in diverse inspirations for medical and technical applications. This requires knowledge of the adhesives themselves in terms of composition, structural design, and interaction with surfaces. This chapter gives an overview about natural adhesives and biological adhesives leading to bioinspired applications. The terminology used in this chapter is based on the adhesive’s origin and usage and the underlying concept: while natural adhesives are composed of bio-based raw materials for artificial applications, biological adhesives are expressed by natural organisms for versatile purposes. The latter in particular can lead to bioinspired applications that are not restricted to adhesion, including concepts to avoid adhesion as in terms of antifouling. Both kinds of adhesive, i.e., natural and biological, are relevant for biocompatible adhesives. This characteristic is mandatory for applications as in cosmetics, food, or medicine. In view of their interaction with vital tissues and their medical eligibility, a brief digression into biomimetic adhesives is given.

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References

  • Annabi N et al (2015) Elastic sealants for surgical applications. Eur J Pharm Biopharm 95(Pt A):27–39

    Article  Google Scholar 

  • Antony AC (1954) Use of fish slime in structural engineering. J Bombay Nat Hist Soc 50(3&4):682–683

    Google Scholar 

  • Babu RP, O’Connor K, Seeram R (2013) Current progress on bio-based polymers and their future trends. Prog Biomater 2:8

    Article  Google Scholar 

  • Balcioglu S et al (2016) Design of xylose-based semisynthetic polyurethane tissue adhesives with enhanced bioactivity properties. ACS Appl Mater Interfaces 8(7):4456–4466

    Article  Google Scholar 

  • Baroncini EA et al (2016) Recent advances in bio-based epoxy resins and bio-based epoxy curing agents. J Appl Polym Sci 133(45):44103

    Article  Google Scholar 

  • Bochynska AI et al (2016) Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions. J Mater Sci Mater Med 27(5):85_1–85_18

    Article  Google Scholar 

  • Boëda E et al (2008) New evidence for significant use of bitumen in Middle Palaeolithic technical systems at Umm el Tlel (Syria) around 70,000 BP. Paléorient 34(2):67–83

    Article  Google Scholar 

  • Buch K et al (2009) Investigation of various shellac grades: additional analysis for identity. Drug Dev Ind Pharm 35(6):694–703

    Article  Google Scholar 

  • Chapman J et al (2014) Bioinspired synthetic macroalgae: examples from nature for antifouling applications. Int Biodeterior Biodegrad 86A:6–13

    Article  Google Scholar 

  • Cohen ER et al (2008) Quantities, units and symbols in physical chemistry. IUPAC/RSC Publishing, Cambridge

    Google Scholar 

  • Cole MR, Hansell MH, Seath CJ (2001) A quantitative study of the physical properties of nest paper in three species of Vespine wasps (Hymenoptera, Vespidae). Insect Soc 48:33–39

    Article  Google Scholar 

  • Eberhard WG (1980) The natural history and behavior of the bolas spider Mastophora dizzydeani sp. n. (Araneidae). Psyche J Entomol 87(3–4):143–169

    Article  Google Scholar 

  • Ehrlich H et al (2013) First report on chitinous holdfast in sponges (Porifera). Proc R Soc B Biol Sci 280(1762):20130339_1–20130339_9

    Article  Google Scholar 

  • Erren TC et al (2013) Oceans of plastics: possible risks of cancer in marine wildlife and humans. In: Allodi S, Nazari EM (eds) Exploring themes on aquatic toxicology. Research Signpost, Trivandrum

    Google Scholar 

  • Evans CW (1977) The ultrastructure of larvae from the marine sponge Halichondria moorei Bergquist (Porifera, Demospongiae). Cah Biol Mar 13:427–433

    Google Scholar 

  • Ferguson J, Nürnberger S, Redl H (2010) Fibrin: the very first biomimetic glue – still a great tool. In: von Byern J, Grunwald I (eds) Biological adhesive systems: from nature to technical and medical application, 1st edn. Springer, Wien/New York

    Google Scholar 

  • Fishelson L (1981) Observation of the moving colonies of the genus Tethya (Desmospongia, Porifera) I. Behaviour and cytology. Zoomorphology 98:89–99

    Article  Google Scholar 

  • Foelix RF et al (2016) Ãœber den Bau der Wohnröhre bei wüstenlebenden Spinnen. Arachne 21(1):4–17

    Google Scholar 

  • Geyer R, Jambeck JR, Law KL (2017) Production, use, and fate of all plastics ever made. Sci Adv 3(7):e1700782_1–e1700782_5

    Article  Google Scholar 

  • Gohad NV et al (2014) Synergistic roles for lipids and proteins in the permanent adhesive of barnacle larvae. Nat Commun 5:4414_1–4414_9

    Article  Google Scholar 

  • Gosline JM et al (1999) The mechanical design of spider silks: from fibroin sequence to mechanical function. J Exp Biol 202(Pt 23):3295–3303

    Google Scholar 

  • Graham LD (2005) Biological adhesives from nature. In: Bowlin GL, Wnek G (eds) Encyclopedia of biomaterials and biomedical engineering. Taylor & Francis, Oxon

    Google Scholar 

  • Graham LD et al (2005) Characterization of a protein-based adhesive elastomer secreted by the Australian frog Notaden bennetti. Biomacromolecules 6(6):3300–3312

    Article  Google Scholar 

  • Greenwood PH (1986) The natural history of African lungfishes. J Morphol 190(Suppl. 1):163–179

    Article  Google Scholar 

  • Gross RA, Kalra B (2002) Biodegradable polymers for the environment. Science 297(5582):803–807

    Article  Google Scholar 

  • Hamwood TE et al (2002) Preliminary characterization and extraction of anterior adhesive secretion in monogenean (platyhelminth) parasites. Folia Parasitol 49:39–49

    Article  Google Scholar 

  • Hennebert E et al (2015) Experimental strategies for the identification and characterization of adhesive proteins in animals: a review. Interface Focus 5(1):20140064

    Article  Google Scholar 

  • Henschel JR (2017) The biology of Leucorchestris arenicola (Araneae: Heteropodidae), a burrowing spider of the Namib dunes. In: Seely MK (ed) Namib ecology: 25 years of Namib research, Transvaal museum monograph, vol 7. Transvaal Museum, Pretoria

    Google Scholar 

  • Hepburn HR et al (1991) Synthesis and secretion of beeswax in henexbees. Apidologie 22:21–36

    Article  Google Scholar 

  • Hon DNS (1989) Cellulosic adhesives. In: Hemingway RW, Conner AH (eds) Adhesives from renewable resources, ACS symposium series, vol 385. American Chemical Society, Washington, DC

    Chapter  Google Scholar 

  • Huang Y et al (2016) Nanospherical arabinogalactan proteins are a key component of the high-strength adhesive secreted by English ivy. Proc Natl Acad Sci U S A 113(23):E3193–E3202

    Article  Google Scholar 

  • Jakobsson S et al (1999) An 11-ketotestosterone induced kidney-secreted protein: the nest building glue from male three-spined stickleback, Gasterosteus aculeatus. Fish Physiol Biochem 20:79–85

    Article  Google Scholar 

  • Karak N (2016) Biopolymers for paints and surface coatings. In: Pacheco-Torgal F, Ivanov V, Karak N, Jonkers H (eds) Biopolymers and biotech admixtures for eco-efficient construction materials, Woodhead publishing series in civil and structural engineering, vol 63. Elsevier, Amsterdam

    Google Scholar 

  • Kearn GC, Evans-Gowing R (1998) Attachment and detachment of the anterior adhesive pads of the monogenean (platyhelminth) parasite Entobdella soleae from the skin of the common sole (Solea solea). Int J Parasitol 28(10):1583–1593

    Article  Google Scholar 

  • Kemp DH, Stone BF, Binnington KC (1982) Tick attachment and feeding: role of the mouthparts, feeding apparatus, salivary gland secretions and the host response. In: Obenchain F, Galun R (eds) Physiology of ticks. Pergamon Press, Oxford

    Google Scholar 

  • Kitzan SM, Sweeny PR (1968) A light and electron microscope study of the structure of Protopterus annectens epidermis. I: mucus production. Can J Zool 46:767–772

    Article  Google Scholar 

  • Klöppel A et al (2013) Detection of bioactive compounds in the mucus nets of Dendropoma maxima, Sowerby 1825 (Prosobranch Gastropod Vermetidae, Mollusca). J Mar Biol 2013:1–9

    Article  Google Scholar 

  • Köckritz A, Martin A (2008) Oxidation of unsaturated fatty acid and vegetable oils. Eur J Lipid Sci Technol 110(9):812–824

    Google Scholar 

  • Koerner L, Gorb SN, Betz O (2012) Functional morphology and adhesive performance of the stick-capture apparatus of the rove beetles Stenus spp. (Coleoptera, Staphylinidae). Zoology 115(2):117–127

    Article  Google Scholar 

  • Kumar Patel A, Mathias JD, Michaud P (2013) Polysaccharides as adhesives: a critical review. Rev Adhes Adhes 1(3):312–345

    Article  Google Scholar 

  • Laursen D (1953) The genus Ianthina. Dana-Report 38:1–40

    Google Scholar 

  • Lebesgue N et al (2016) Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: a quantitative proteomics approach. J Proteome 138:61–71

    Article  Google Scholar 

  • Lee C et al (2013) Bioinspired, calcium-free alginate hydrogels with tunable physical and mechanical properties and improved biocompatibility. Biomacromolecules 14(6):2004–2013

    Article  Google Scholar 

  • Lengerer B et al (2016) Adhesive organ regeneration in Macrostomum lignano. BMC Dev Biol 16(20):1–16

    Google Scholar 

  • Lengerer B et al (2017) Organ specific gene expression in the regenerating tail of Macrostomum lignano. Dev Biol. https://doi.org/10.1016/j.ydbio.2017.07.021

  • Li A, Li K (2014) Pressure-sensitive adhesives based on epoxidized soybean oil and dicarboxylic acids. ACS Sustain Chem Eng 2(8):2090–2096

    Article  Google Scholar 

  • Li J et al (2017) Tough adhesives for diverse wet surfaces. Science 357(6349):378–381

    Article  Google Scholar 

  • Maiorana A et al (2015) Bio-based epoxy resin toughening with cashew nut shell liquid-derived resin. Green Mater 3(3):80–92

    Article  Google Scholar 

  • Mann LK et al (2012) Fetal membrane patch and biomimetic adhesive coacervates as a sealant for fetoscopic defects. Acta Biomater 8(6):2160–2165

    Article  Google Scholar 

  • Mathias JD, Grédiac M, Michaud P (2016) Bio-based adhesives. In: Pacheco-Torgal F, Ivanov V, Karak N, Jonkers H (eds) Biopolymers and biotech admixtures for eco-efficient construction materials, Woodhead publishing series in civil and structural engineering, vol 63. Elsevier, Amsterdam

    Google Scholar 

  • McGovern JN, Jeanne RL, Effland MJ (1988) The nature of wasp nest paper. TAPPI J 71(12):133–139

    Google Scholar 

  • Melzer B et al (2010) The attachment strategy of English ivy: a complex mechanism acting on several hierarchical levels. J R Soc Interface 7:1383–1389

    Article  Google Scholar 

  • Meyer-Rochow VB (1979) The attachment mechanism of the waterflea Simocephalus. Microscopy 33: 551–553 & 558

    Google Scholar 

  • Meyer-Rochow VB (2007) Glowworms: a review of Arachnocampa spp. and kin. Luminescence 22:251–265

    Article  Google Scholar 

  • Meyer-Rochow VB et al (2015) Commentary: Plastic ocean and the cancer connection: 7 questions and answers. Environ Res 142:575–578

    Article  Google Scholar 

  • Michel HB (1984) Chaetognatha of the Caribbean Sea and adjacent areas, NOAA technical report NMFS, vol 15. NOAA/National Marine Fisheries Service, Seattle

    Google Scholar 

  • Miller SL (1974) Adaptive design of locomotion and foot form in prosobranch gastropods. J Exp Mar Biol Ecol 14(2):99–156

    Article  Google Scholar 

  • Miserez A et al (2008) The transition from stiff to compliant materials in squid beaks. Science 319:1816–1819

    Article  Google Scholar 

  • Mohajerani A et al (2017) Physico-mechanical properties of asphalt concrete incorporated with encapsulated cigarette butts. Constr Build Mater 153:69–80

    Article  Google Scholar 

  • NPCS Board of Consultants & Engineers (2017) The complete book on adhesives, glues & resins technology (with process & formulations). Asia Pacific Business Press Inc, Delhi

    Google Scholar 

  • Nutting WL, Blum MS, Fales HM (1974) Behaviour of the North American termite Tenuirostritermes tenuirostris, with special reference to the soldier frontal gland secretion, its chemical composition and use in defense. Psyche 84(1):167–177

    Article  Google Scholar 

  • Oda M et al (1998) Study on food components: the structure of N-linked asialo carbohydrate from the edible bird’s nest built by Collocalia fuciphaga. J Agric Food Chem 46:3047–3053

    Article  Google Scholar 

  • Papanna R et al (2015) Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites. Placenta 36(8):888–894

    Article  Google Scholar 

  • Papanna R et al (2016) Cryopreserved human umbilical cord patch for in-utero spina bifida repair. Ultrasound Obstet Gynecol 47(2):168–176

    Article  Google Scholar 

  • Patachia S, Croitoru C (2016) Biopolymers for wood preservation. In: Pacheco-Torgal F, Ivanov V, Karak N, Jonkers H (eds) Biopolymers and biotech admixtures for eco-efficient construction materials, Woodhead publishing series in civil and structural engineering, vol 63. Elsevier, Amsterdam

    Google Scholar 

  • Penning M (1996) Aqueous shellac solutions for controlled release coatings. In: Karsa DR, Stephenson RA (eds) Chemical aspects of drug delivery systems. The Royal Society of Chemistry, Cambridge

    Google Scholar 

  • Poulsen N et al (2014) Isolation and biochemical characterization of underwater adhesives from diatoms. Biofouling 30(4):513–23

    Google Scholar 

  • Rischka K et al (2010) Bio-inspired polyphenolic adhesives for medical and technical applications. In: von Byern J, Grunwald I (eds) Biological adhesive systems: from nature to technical and medical application, 1st edn. Springer, Wien/NewYork

    Google Scholar 

  • Rodrigues M et al (2016) Profiling of adhesive-related genes in the freshwater cnidarian Hydra magnipapillata by transcriptomics and proteomics. Biofouling 32(9):1115–1129

    Article  Google Scholar 

  • Sahni V et al (2014) Prey capture adhesives produced by orb-weaving spiders. In: Asakura T, Miller T (eds) Biotechnology of silk. Springer, Dordrecht

    Google Scholar 

  • Sankaranarayanan Y (1989) Adhesives & Shellac. Shellac Export Promotion Council, Calcutta

    Google Scholar 

  • Schlee D, Ebel F (1983) Note on the chemical nature of the adhesive of viscid discs in Catasetum fimbriatum Lindl. (Orchidaceae). Am J Bot 70(6):872–876

    Article  Google Scholar 

  • Schwotzer W et al (2012) Biologische und biomimetische Klebstoffe (Teil 2) – Praxistauglichkeit und Trends. Adhäsion 10:38–43

    Google Scholar 

  • Shibata M (2013) Bio-based epoxy resin/clay nanocomposites. In: Mittal V (ed) Thermoset nanocomposites. Wiley-VCH Verlag, Weinheim

    Google Scholar 

  • Shirtcliffe NJ, McHale G, Newton MI (2012) Wet adhesion and adhesive locomotion of snails on anti-adhesive non-wetting surfaces. PLoS One 7(5), e36983. https://doi.org/10.1371/journal.pone.0036983

  • Singer TL, Espelie KE, Himmelsbach DS (1992) Ultrastructural and chemical examination of paper and pedicel from laboratory and field nests of the social wasp Polistes metricus say. J Chem Ecol 18(1):77–86

    Article  Google Scholar 

  • Smith AM (2016) Biological adhesives. Springer, Cham

    Book  Google Scholar 

  • Smith AM, Callow JA (2006) Biological adhesives. Springer, Heidelberg

    Book  Google Scholar 

  • Specht F et al (1998) The application of shellac acidic polymer for enteric coating. Pharm Technol 10:20–28

    Google Scholar 

  • Spotnitz WD, Burks S (2008) Hemostats, sealants, and adhesives: components of the surgical toolbox. Transfusion 48(7):1502–1516

    Article  Google Scholar 

  • Stabili L et al (2015) The mucus of Actinia equina (Anthozoa, Cnidaria): an unexplored resource for potential applicative purposes. Mar Drugs 13(8):5276–5296

    Article  Google Scholar 

  • Stevens CL, Hurd CL, Smith MJ (2002) Field measurement of the dynamics of the bull kelp Durvillaea antarctica (Chamisso) Heriot. J Exp Mar Biol Ecol 269:147–171

    Article  Google Scholar 

  • Sung HW et al (1998) Feasibility study of a natural crosslinking reagent for biological tissue fixation. J Biomed Mater Res 42(4):560–567

    Article  Google Scholar 

  • Suppan J et al (2017) Tick attachment cement – reviewing the mysteries of a biological skin plug system. Biol Rev. https://doi.org/10.1111/brv.12384

  • Tulloch AP (1970) The composition of beeswax and other waxes secreted by insects. Lipids 5(2):247–258

    Article  Google Scholar 

  • Türk O (2014) Stoffliche Nutzung nachwachsender Rohstoffe. Grundlagen – Werkstoffe – Anwendungen. Springer, Wiesbaden

    Book  Google Scholar 

  • Türünc O et al (2015) From plant oils to plant foils: straightforward functionalization and crosslinking of natural plant oils with triazolinediones. Eur Polym J 65:286–297

    Article  Google Scholar 

  • van der Kooij D, Van der Wielen PWJJ (2014) Microbial growth in drinking-water supplies: problems, causes, control and research needs. IWA Publishing, London

    Google Scholar 

  • Van Iersel JJA (1953) An analysis of the parental behaviour of the male three-spined stickleback (Gasterosteus aculeatus L.). E. J. Brill, Leiden

    Google Scholar 

  • Vandevivere P, Kirchman DL (1993) Attachment stimulates exopolysaccharide synthesis by a bacterium. Appl Environ Microbiol 59(10):3280–3286

    Google Scholar 

  • von Byern J, Grunwald I (2010) Biological adhesive systems: from nature to technical and medical application. Springer, Wien/NewYork

    Book  Google Scholar 

  • von Byern J et al (2017) Chemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae). Sci Rep 7(1):6647_1–6647_13

    Google Scholar 

  • von Byern J et al (2018) Examples of bioadhesives for defence and predation. In: Gorb SN, Gorb EV (eds) Functional surfaces in biology III: diversity of the physical phenomena. Biologically-inspired systems, vol 10. Springer International Publishing AG, p XV, 268

    Google Scholar 

  • Waugh DG et al (2016) Surface treatments to modulate bioadhesion: a critical review. Rev Adhes Adhes 4(1):69–103

    Article  Google Scholar 

  • Weakley FB, Mehltretter CL (1965) Low cost protein glue for southern pine plywood. For Prod J 15(1):8–12

    Google Scholar 

  • Wilks AM et al (2015) Double-network gels and the toughness of terrestrial slug glue. J Exp Biol 218(Pt 19):3128–3137

    Article  Google Scholar 

  • Wu Y, Li A, Li K (2015) Pressure sensitive adhesives based on oleic acid. J Am Oil Chem Soc 92(1):111–120

    Article  Google Scholar 

  • Yang X, Deng W (2017) Morphological and structural characterization of the attachment system in aerial roots of Syngonium podophyllum. Planta 245(3):507–521

    Article  Google Scholar 

  • Yeargan KV (1994) Biology of bolas spiders. Annu Rev Entomol 39:81–99

    Article  Google Scholar 

  • Zheden V et al (2015) Mechanical properties of the cement of the stalked barnacle Dosima fascicularis (Cirripedia, Crustacea). Interface Focus 5(1):20140049

    Article  Google Scholar 

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Correspondence to Katharina Richter or Ingo Grunwald .

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Richter, K., Grunwald, I., von Byern, J. (2018). Bioadhesives. In: da Silva, L., Oechsner, A., Adams, R. (eds) Handbook of Adhesion Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-42087-5_53-2

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