Basal Cell Carcinoma of the Anal Margin
Basal cell carcinoma of the anal margin is a malignant epithelial neoplasm. It consists of basaloid cells, and on microscopic examination, it is similar to conventional basal cell carcinoma of the skin (Gibson and Ahmed 2001).
The etiology of this tumor is unknown, but there is neither an evidence for a role of infection by HPV nor a role of ultraviolet radiation, unlike other basal cell carcinoma occurring in the sun-exposed skin. Some patients have a history of radiotherapy in the pelvic area. For some authors, the occurrence of this tumor could be favored by chronic skin irritation or a local trauma.
References and Further Reading
- Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology & Laboratory Medicine, 134, 1601–1611.Google Scholar