Pseudogoblet cells are distended columnar epithelial cells that mimic goblet cells. They are commonly detected in columnar-lined esophagus. These cells are important to recognize, since they are indicators of intestinal metaplasia in the esophagus and a diagnostic criterion of the Barrett esophagus according to the American College of Gastroenterology. The recognition of goblet cells guides the surveillance protocol, although the clinical validity has been debated, and thus it is vital to appreciate the histology and histochemical staining properties of pseudogoblet cells in order to differentiate them from goblet cells.
Histology of Goblet Cells Versus Pseudogoblet Cells
Goblet cells are mucin-producing cells normally present in the intestine (small and large), respiratory tract, and conjunctiva. They result from the accumulation of tightly packed large mucin granules at the cellular apex and consequently have a distinctive flask or wine goblet shape. The basal portion of the...
References and Further Reading
- Bronner, M. P. (2004). Inflammatory disorders of the GI tract: Inflammatory disorders of the esophagus. In R. D. Odze, J. R. Goldblum, & J. M. Crawford (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas (1st ed., pp. 121–1423). Philadelphia: Saunders.Google Scholar
- Ovalle, W. K., & Nahirney, P. C. (2013). Lower digestive system. In W. K. Ovalle & P. C. Nahirney (Eds.), Netter’s essential histology (2nd ed., pp. 285–309). Philadelphia: Saunders.Google Scholar
- Younes, M., Ertan, A., Ergun, G., Verm, R., Bridges, M., Woods, K., Meriano, F., Schmulen, A. C., Colman, R., Johnson, C., Barroso, A., Schwartz, J., McKechnie, J., Lechago, J., et al. (2007). Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Archives of Pathology & Laboratory Medicine, 131(4), 571–575.Google Scholar