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Mucinous Carcinoma, Upper Gastrointestinal Tract

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Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Colloid carcinoma; Mucinous adenocarcinoma; Mucoid carcinoma

Definition

Mucinous carcinoma is one of the five main types of gastric adenocarcinoma in the World Health Organization (WHO) classification scheme. These adenocarcinomas are characterized by the production of abundant intracellular and extracellular mucus; by convention, more than 50% of the tumor consists of extracellular mucus.

Clinical Features

  • Incidence

    Gastric carcinoma accounts for the fifth most common form of cancer worldwide. Mucinous gastric carcinoma compromises approximately 2–5% of all gastric carcinomas.

  • Age

    Incidence increases progressively with age and is not different from other types of gastric carcinoma.

  • Sex

    Men are more at risk of developing gastric cancer than women. In the study of Choi et al., 77% of patients with mucinous gastric carcinoma were men, while in non-mucinous gastric carcinoma, 67% were men.

  • Site

    The entire stomach can be involved; most frequently, mucinous gastric carcinomas are...

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References and Further Reading

  • Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2010). WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.

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  • Choi, J. S., Kim, M. A., Lee, H. E., Lee, H. S., & Kim, W. H. (2009). Mucinous gastric carcinomas: Clinicopathologic and molecular analyses. Cancer, 115(15), 3581–3590.

    Article  CAS  Google Scholar 

  • Chu, P. G., Chung, L., Weiss, L. M., & Lau, S. K. (2011). Determining the site of origin of mucinous adenocarcinoma: An immunohistochemical study of 175 cases. The American Journal of Surgical Pathology, 35(12), 1830–1836.

    Article  Google Scholar 

  • Sung, C. O., Lee, S. M., Choi, J. S., Kim, K. M., Choi, M. G., Noh, J. H., et al. (2012). Tumor size predicts survival in mucinous gastric carcinoma. Journal of Surgical Oncology, 106(6), 757–764.

    Article  CAS  Google Scholar 

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Correspondence to Chella R. S. van der Post .

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van der Post, C.R., Carneiro, F. (2017). Mucinous Carcinoma, Upper Gastrointestinal Tract. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1654

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1654

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

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