Giant hypertrophic gastritis; Giant mucosal rugae; Hyperplastic gastropathy; Hyperplastic/Hypertrophic gastritis; Hypoproteinemic hypertrophic gastropathy; Protein-losing gastropathy
Ménétrier’s disease is a rare form of acquired gastropathy involving the gastric fundus and corpus and is characterized by gastric rugal hypertrophy, protein-losing gastropathy, and an increase of gastric luminal pH (hypochlorhydria).
Ménétrier’s disease is considered to be a rare acquired disorder of uncertain etiology. It was first described in 1888 by Pierre Ménétrier, a French pathologist who observed enlarged gastric folds during autopsies. Sporadic case reports were described in the following decennia; in most adult cases, an initial pathogenic agent or event could not be determined. A break-through in the pathogenesis was the finding of local overproduction of transforming growth factor-alpha (TGF-α), resulting in enhanced epidermal growth factor receptor (EGFR) signaling in the...
References and Further Reading
- Dempsey, P. J., Goldenring, J. R., Soroka, C. J., Modlin, I. M., McClure, R. W., Lind, C. D., et al. (1992). Possible role of transforming growth factor alpha in the pathogenesis of Menetrier’s disease: supportive evidence form humans and transgenic mice. Gastroenterology, 103(6), 1950–1963.CrossRefGoogle Scholar