Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Lymphoepithelioma-Like Carcinoma

  • Helena BaldaiaEmail author
Reference work entry


Gastric carcinoma with a lymphoid stroma; Lymphoepithelial-like carcinomas; Medullary carcinoma with lymphocytic infiltration; Undifferentiated carcinoma with lymphoid stroma


Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma with prominent lymphoid stroma (Glickman and Odze 2009), which is similar to nasopharyngeal carcinomas. This type of tumor has been described in a number of extragastrointestinal sites, such as thyroid or breast, and also along the gastrointestinal tract (Delaney and Chetty2012). In the latter, the most commonly reported site is the stomach, but cases arising in the esophagus and colon have been described (Delaney and Chetty2012). Rarely, this type of tumor has been reported in the liver and biliary tree (Ishida et al. 2011).

LELC has been classically associated with Epstein-Barr virus (EBV) infection. In the stomach, more than 80% of cases have evidence of EBV infection, while in esophageal LELC, in one study, only 3%...

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References and Further Reading

  1. Delaney, D., & Chetty, R. (2012). Lymphoepithelioma-like carcinoma of the colon. International Journal of Clinical and Experimental Pathology, 5(1), 105–110.PubMedPubMedCentralGoogle Scholar
  2. Fukayama, M., & Ushiku, T. (2011). Epstein-Barr virus-associated gastric carcinoma. Pathology, Research and Practice, 207(9), 529–537.CrossRefGoogle Scholar
  3. Glickman, J., & Odze, R. D. (2009). Epithelial neoplasms of the esophagus. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  4. Ishida, M., Mori, T., Shiomi, H., et al. (2011). Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct. World Journal of Gastrointestinal Oncology, 3(7), 111–115.CrossRefGoogle Scholar
  5. Kojima, Y., Mogaki, M., Takagawa, R., et al. (2007). A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. Journal of Gastroenterology, 42(2), 181–185.CrossRefGoogle Scholar
  6. Lauwers, G. Y. (2009). Epithelial neoplasms of the stomach. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  7. Lee, W. (2011). Intrahepatic lymphoepithelioma-like cholangiocarcinoma not associated with Epstein-Barr virus: A case report. Case Reports in Oncology, 4(1), 68–73.CrossRefGoogle Scholar
  8. Nakasono, M., Hirokawa, M., Suzuki, M., et al. (2007). Lymphoepithelioma-like carcinoma of the esophagus: Report of a case with non-progressive behavior. Journal of Gastroenterology and Hepatology, 22(12), 2344–2347.CrossRefGoogle Scholar
  9. Tamura, T., Hamada, T., Sako, T., et al. (2010). Lymphoepithelioma-like carcinoma of the stomach with epithelioid granulomas. Case Reports in Gastroenterology, 4(3), 361–368.CrossRefGoogle Scholar
  10. Wang, H., Wu, M., Shun, C., et al. (1999). Lymphoepithelioma-like carcinoma of the stomach: A subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection. Hepato-Gastroenterology, 46(26), 1214–1219.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal