Gastric carcinoma with a lymphoid stroma; Lymphoepithelial-like carcinomas; Medullary carcinoma with lymphocytic infiltration; Undifferentiated carcinoma with lymphoid stroma
Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma with prominent lymphoid stroma (Glickman and Odze 2009), which is similar to nasopharyngeal carcinomas. This type of tumor has been described in a number of extragastrointestinal sites, such as thyroid or breast, and also along the gastrointestinal tract (Delaney and Chetty2012). In the latter, the most commonly reported site is the stomach, but cases arising in the esophagus and colon have been described (Delaney and Chetty2012). Rarely, this type of tumor has been reported in the liver and biliary tree (Ishida et al. 2011).
LELC has been classically associated with Epstein-Barr virus (EBV) infection. In the stomach, more than 80% of cases have evidence of EBV infection, while in esophageal LELC, in one study, only 3%...
References and Further Reading
- Glickman, J., & Odze, R. D. (2009). Epithelial neoplasms of the esophagus. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
- Lauwers, G. Y. (2009). Epithelial neoplasms of the stomach. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar