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Pathology of the Gastrointestinal Tract pp 389–392Cite as

Inflammatory Fibroid Polyp, Upper Gastrointestinal Tract

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Eosinophilic granuloma; Eosinophilic pseudotumor; Granuloblastoma; Submucosal granuloma with eosinophilic infiltration; Vanek’s polyp/tumor

Definition

Inflammatory fibroid polyp is a benign submucosal tumor composed of bland spindle and/or stellate mesenchymal cells and edematous/myxoid stroma with prominent vasculature and inflammatory cells comprising eosinophils, lymphocytes, plasma cells, and mast cells (Bhattacharya 2012; Turner and Odze 2009). Despite many ultrastructural and immunohistochemical studies suggesting dendritic, fibroblastic, fibrohistiocytic, histiocytic, myofibroblastic, neural, and vascular differentiation, an origin of spindle cells comprising these polyps remains controversial. The consistent PDGFRA (platelet-derived growth factor receptor alpha) expression seen in gastric and small intestinal inflammatory fibroid polyps points to the fact that these tumors might develop from a subset of PDGFRA-positive mesenchymal cells (Lasota et al. 2009).

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References and Further Reading

  • Bhattacharya, B. (2012). Non-neoplastic disorders of the stomach. In C. A. Iacobuzio-Doahue & E. Montgomery (Eds.), Gastrointestinal and liver pathology (pp. 130–133). Philadelphia: Saunders Elsevier.

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  • Daum, O., Hatlova, J., Mandys, V., Grossmann, P., Mukensnabl, P., Benes, Z., & Michal, M. (2010). Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek’s tumors). Virchows Archiv, 456, 491–497.

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  • Huss, S., Wardelmann, E., Goltz, D., Binot, E., Wolfgang Hartmann, W., Merkelbach-Bruse, S., Buttner, R., & Schildhaus, H.-U. (2012). Activating PDGFRA mutations in inflammatory fibroid polypsoccur in exons 12, 14 and 18 and are associated with tumour localization. Histopathology, 61, 59–68.

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  • Lasota, J., Wang, Z.-F., Sobin, L. H., & Miettinen, M. (2009). Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Modern Pathology, 22, 1049–1056.

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  • Schildhaus, H.-U., Cavlar, T., Binot, E., Buttner, R., Wardelmann, E., & Merkelbach-Bruse, S. (2008). Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. Journal of Pathology, 216, 176–182.

    Article  CAS  Google Scholar 

  • Solte, M., & Finkenzeller, G. (1990). Inflammatory fibroid polyp of the stomach. Endoscopy, 22, 203–207.

    Article  Google Scholar 

  • Turner, J. R., & Odze, R. D. (2009). Polyps of stomach. In R. D. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas (pp. 439–441). Philadelphia: Saunders Elsevier.

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Author information

Authors and Affiliations

  1. Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of Porto, 4200-465, Porto, Portugal

    José Manuel Lopes

Authors
  1. José Manuel Lopes
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Corresponding author

Correspondence to José Manuel Lopes .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Lopes, J.M. (2017). Inflammatory Fibroid Polyp, Upper Gastrointestinal Tract. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1639

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1639

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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