Inflammatory Fibroid Polyp, Upper Gastrointestinal Tract
Eosinophilic granuloma; Eosinophilic pseudotumor; Granuloblastoma; Submucosal granuloma with eosinophilic infiltration; Vanek’s polyp/tumor
Inflammatory fibroid polyp is a benign submucosal tumor composed of bland spindle and/or stellate mesenchymal cells and edematous/myxoid stroma with prominent vasculature and inflammatory cells comprising eosinophils, lymphocytes, plasma cells, and mast cells (Bhattacharya 2012; Turner and Odze 2009). Despite many ultrastructural and immunohistochemical studies suggesting dendritic, fibroblastic, fibrohistiocytic, histiocytic, myofibroblastic, neural, and vascular differentiation, an origin of spindle cells comprising these polyps remains controversial. The consistent PDGFRA (platelet-derived growth factor receptor alpha) expression seen in gastric and small intestinal inflammatory fibroid polyps points to the fact that these tumors might develop from a subset of PDGFRA-positive mesenchymal cells (Lasota et al. 2009).
References and Further Reading
- Bhattacharya, B. (2012). Non-neoplastic disorders of the stomach. In C. A. Iacobuzio-Doahue & E. Montgomery (Eds.), Gastrointestinal and liver pathology (pp. 130–133). Philadelphia: Saunders Elsevier.Google Scholar
- Huss, S., Wardelmann, E., Goltz, D., Binot, E., Wolfgang Hartmann, W., Merkelbach-Bruse, S., Buttner, R., & Schildhaus, H.-U. (2012). Activating PDGFRA mutations in inflammatory fibroid polypsoccur in exons 12, 14 and 18 and are associated with tumour localization. Histopathology, 61, 59–68.CrossRefPubMedGoogle Scholar
- Turner, J. R., & Odze, R. D. (2009). Polyps of stomach. In R. D. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas (pp. 439–441). Philadelphia: Saunders Elsevier.Google Scholar