Hyperplastic Polyps (Stomach)
Gastritis polyposa; Hyperplasiogenic polyp; Inflammatory polyp; Regenerative polyp
Hyperplastic polyps are localized, non-neoplastic mucosal expansions consisting of elongated, tortuous, and cystically dilated foveolae supported by an edematous lamina propria and distended vessels. Hyperplastic polyps arise probably as a result of reparative and regenerative responses to mucosal injury. First there is ongoing healing and a reparative response in the form of foveolar hyperplasia after mucosal injury and erosion. This hyperplastic reaction can end or persist and progress with the formation of a hyperplastic polyp. The common causative agents of mucosal injury are Helicobacter pylori and autoimmune gastritis leading to chronic gastritis, although any agent causing chronic gastritis may be a predisposing condition. H. pylorihas been shown to increase the expression of cyclo-oxygenase-2 (COX-2), interleukin 1-beta, and hepatocyte growth factor in stromal cells, which...